CD200R1 Protein (AA 27-266) (His tag)
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- Target See all CD200R1 Proteins
- CD200R1 (CD200 Receptor 1 (CD200R1))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 27-266
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CD200R1 protein is labelled with His tag.
- Characteristics
- Human CD200 R1 / CRTR2 Protein, His Tag
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CD200R1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- CD200R1 (CD200 Receptor 1 (CD200R1))
- Alternative Name
- CD200 R1 (CD200R1 Products)
- Synonyms
- CD200R Protein, HCRTR2 Protein, MOX2R Protein, OX2R Protein, Mox2r Protein, CD200R1 Protein, CD200R2 Protein, CD200R-B1V1 Protein, CD200R1A Protein, CD200 receptor 1 Protein, cell surface glycoprotein CD200 receptor 1 Protein, CD200 receptor 1-like Protein, CD200R1 Protein, Cd200r1 Protein, LOC487977 Protein, CD200R1L Protein
- Background
- Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. CD200 and its receptor CD200R are both type-1 membrane glycoproteins, which are members of the immunoglobulin superfamily (IgSF). Besides the inhibitory effect on macrophages, CD200/CD200R also play an important role in regulating the regulatory T cells, allergicreaction, autoimmune diseases, allograft, neurological diseases and other autoimmune-related diseases. The interaction between CD200, which is mainly present in neurons but also in astrocytes, and CD200R1, which is mainly present in microglia, is one of the mechanisms involved in keeping the microglial proinflammatory phenotype under control in physiological conditions. Alterations in the expression of CD200 and CD200R1 have been described in neurodegenerative diseases, but little is known about the mechanism of regulation of these proteins under physiological or pathological conditions.
- Molecular Weight
- 28.7 kDa
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