ALK Protein (Fc Tag)

Catalog No. ABIN7272289

Product Details

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This ALK protein is labelled with Fc Tag.

Purpose: Recombinant Human ALK Protein with C-terminal human Fc tag

Specificity: ALK (Ser31-Gln692) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: affinity purification

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Alternative Name: ALK (ALK Products)

Synonyms: Tcrz Protein, CD246 Protein, NBLST3 Protein, ALK Protein, anaplastic lymphoma kinase Protein, anaplastic lymphoma receptor tyrosine kinase Protein, ALK receptor tyrosine kinase Protein, Alk Protein, ALK Protein

Background: Synonymes: CD246, NBLST3
Description: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

Molecular Weight: predicted molecular mass of 136.4 kDa after removal of the signal peptide.The apparent molecular mass of ALK-hFc is 130-250 kDa due to glycosylation.

UniProt: Q9UM73

Pathways: RTK Signaling