BIM Protein (His tag)
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- Target See all BIM (BCL2L11) Proteins
- BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This BIM protein is labelled with His tag.
- Purpose
- Recombinant Human BIM/BCL2L11 Protein (His Tag)
- Sequence
- Met1-Arg120
- Characteristics
- Recombinant Human Bcl-2-like Protein 11 is produced by our E.coli expression system and the target gene encoding Met1-Arg120 is expressed with a 6His tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product BCL2L11 Protein
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BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-109) protein (GST tag)
BCL2L11 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-112) protein (GST tag)BCL2L11 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-100) protein (GST tag)BCL2L11 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-198) protein (Strep Tag)Crystallography grade BCL2L11 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-196) protein (Strep Tag)Crystallography grade BCL2L11 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-198), (full length) protein (His-SUMO Tag)BCL2L11 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-198), (full length) protein (His tag)BCL2L11 Origin: Human Host: Yeast Recombinant > 90 % SDS
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM HEPES, 150 mM NaCl, 10 % glycerol, 2 mM DTT, pH 8.0.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
- Alternative Name
- BIM/BCL2L11 (BCL2L11 Products)
- Synonyms
- bim Protein, BAM Protein, BIM Protein, BOD Protein, 1500006F24Rik Protein, Bim Protein, Bod Protein, BimL Protein, BIMEL Protein, BCL2-like 11 Protein, BCL2 like 11 Protein, BCL2-like 11 (apoptosis facilitator) Protein, bcl2l11 Protein, BCL2L11 Protein, Bcl2l11 Protein
- Background
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Background: BIML is one of several splice variants of BIM, a proapoptotic protein belonging to the BH-3 domain-only subgroup of Bcl-2 family members. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BIML is thought to promote apoptosis by binding and inhibiting the activity of anti-apoptotic Bcl-2 family members, thereby inducing the release of cytochrome c from mitochondria. BIML is normally sequestered in an inactive conformation from anti-apoptotic Bcl-2 family members through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release BIML from microtubules to neutralize anti-apoptotic Bcl-2 family members, allowing for the initiation of apoptosis.
Synonym: Bcl-2-like protein 11, Bcl2-L-11, Bcl2-interacting mediator of cell death, BCL2L11, BIM, BIML
- Molecular Weight
- 15 kDa
- Pathways
- PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
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