CES2 Protein (His tag)

Catalog No. ABIN7194592

Product Details

Target: CES2 (Carboxylesterase 2 (CES2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This CES2 protein is labelled with His tag.

Purpose: Recombinant Mouse Carboxylesterase-2/CES2 Protein (His Tag)(Active)

Sequence: Met 1-Lys 557

Characteristics: A DNA sequence encoding the extracellular domain of mouse CES2 (NP_663578.1) (Met 1-Lys 557) was expressed, with a polyhistidine tag at the C-terminus.

Purity: > 85 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to hydrolyze pnitrophenylacetate. The specific activity is >90,000 pmoles/min/μg.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CES2 (Carboxylesterase 2 (CES2))

Alternative Name: Carboxylesterase-2/CES2 (CES2 Products)

Synonyms: CE-2 Protein, CES2A1 Protein, PCE-2 Protein, iCE Protein, Ces2 Protein, im:6908784 Protein, si:dkey-38l12.2 Protein, zgc:153863 Protein, ce-2 Protein, ces2a1 Protein, pce-2 Protein, carboxylesterase 2 Protein, liver carboxylesterase 2 Protein, cocaine esterase Protein, carboxylesterase 2 (intestine, liver) Protein, CES2 Protein, Ces2 Protein, LOC100343300 Protein, LOC100734360 Protein, ces2 Protein

Background:

Background: Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.

Synonym: ces2A3

Molecular Weight: 60.4 kDa

NCBI Accession: NP_663578