Cathepsin Z Protein (CTSZ) (His tag)
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- Target See all Cathepsin Z (CTSZ) Proteins
- Cathepsin Z (CTSZ)
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Cathepsin Z protein is labelled with His tag.
- Purpose
- Recombinant Human Cathepsin Z Protein (His Tag)(Active)
- Sequence
- Met 1-Val 303
- Characteristics
- A DNA sequence encoding the human CTSZ (Q9UBR2) (Met 1-Val 303) was fused with a polyhistidine tag at the C-terminus.
- Purity
- > 97 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp)-OH,R&D Systems, Catalog # ES005.The specific activity is >800 pmoles/min/μg.
- Top Product
- Discover our top product CTSZ Protein
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Cathepsin Z (CTSZ) (AA 1-303) protein (GST tag)
CTSZ Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cathepsin Z (CTSZ) (Active) protein (His tag)CTSZ Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Cathepsin Z (CTSZ)
- Alternative Name
- Cathepsin Z (CTSZ Products)
- Synonyms
- wu:fj81f10 Protein, zgc:103420 Protein, CTSZ Protein, CTSX Protein, AI787083 Protein, AU019819 Protein, D2Wsu143e Protein, CATX Protein, CathePsin Z Protein, cathepsin Z Protein, cathepsin Z S homeolog Protein, papain family cysteine protease Protein, cpz-1 Protein, cpz-2 Protein, CTSZ Protein, ctsz Protein, ctsz.S Protein, TTHERM_00102779 Protein, NAEGRDRAFT_78125 Protein, Ctsz Protein
- Background
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Background: Cathepsin Z (CTSZ); also known as Cathepsin X or CATX; belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘mini loop’. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus; and in contrast to cathepsin B; it does not act as an endopeptidase. It is restricted to the cells of theimmune system; predominantly monocytes; macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues; suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells; a process; which is crucial in the initiation of adaptive immunity. Furthermore; higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa; especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources; suggesting that this enzyme may participate in tumor progression.
Synonym: Cathepsin Z; Cathepsin P; Cathepsin X; CTSZ
- Molecular Weight
- 33 kDa
- UniProt
- Q9UBR2
- Pathways
- Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones
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