CD84 Protein (CD84) (AA 1-225) (His tag)

Catalog No. ABIN7318041

Product Details

Target: CD84

Protein Type: Recombinant

Protein Characteristics: AA 1-225

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CD84 protein is labelled with His tag.

Purpose: Recombinant Human SLAMF5/CD84 Protein (aa 1-225, His Tag)

Sequence: Met 1-Gly 225

Characteristics: A DNA sequence encoding the extracellular domain (Met 1-Gly 225) of human CD84 (NP_003865.1) was expressed with a C-terminal polyhistidine tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD84

Alternative Name: SLAMF5/CD84 (CD84 Products)

Synonyms: RGD1564553 Protein, A130013D22Rik Protein, CDw84 Protein, SLAMF5 Protein, LY9B Protein, hCD84 Protein, mCD84 Protein, CD84 molecule Protein, CD84 antigen Protein, Cd84 Protein, CD84 Protein

Background:

Background: The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. The CD84-CD84 interaction was independent of its cytoplasmic tail. Thus, CD84 is its own ligand and acts as a costimulatory molecule. CD84 is expressed on cells from almost all hematopoietic lineages and on CD34+ hematopoietic progenitor cells, suggesting that CD84 serves as a marker for committed hematopoietic progenitor cells.

Synonym: SLAM family member 5, Cell surface antigen MAX.3, Hly9-beta, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5, CD84, SLAMF5,hCD84,LY9B,mCD84

Molecular Weight: 24 kDa

NCBI Accession: NP_003865