CADM3 Protein (Fc Tag)

Catalog No. ABIN7321188

Product Details

Target: CADM3 (Cell Adhesion Molecule 3 (CADM3))

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purification tag / Conjugate: This CADM3 protein is labelled with Fc Tag.

Purpose: Recombinant Rat CADM3 Protein (Fc Tag)

Sequence: Met1-His328

Characteristics: A DNA sequence encoding the rat CADM3 (Q1WIM3) (Met1-His328) was expressed with the Fc region of human IgG1 at the C-terminus.

Purity: > 85 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CADM3 (Cell Adhesion Molecule 3 (CADM3))

Alternative Name: CADM3 (CADM3 Products)

Synonyms: BIgR Protein, IGSF4B Protein, NECL1 Protein, Necl-1 Protein, TSLL1 Protein, synCAM3 Protein, Igsf4b Protein, Necl1 Protein, SynCAM3 Protein, Tsll1 Protein, necl1 Protein, cell adhesion molecule 3 Protein, cell adhesion molecule 3 S homeolog Protein, CADM3 Protein, Cadm3 Protein, cadm3.S Protein

Background:

Background: Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind (homophilic binding) or with other CAMs or the extracellular matrix (heterophilic binding). Cell adhesion molecule 3, also known as Immunoglobulin superfamily member 4B, CADM3, and NECL1, is a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule which has Ca(2+)-independent homo- or heterophilic cell-cell adhesion activity and plays an important role in the formation of synapses, axon bundles and myelinated axons. Isoform 1 of CADM3 is expressed mainly in adult and fetal brain. Isoform 2 of CADM3 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. CADM3 is involved in the cell-cell adhesion. It has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. The interaction with EPB41L1 may regulate structure or function of cell-cell junctions. CADM3 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation.

Synonym: CADM3,Igsf4b,Necl1,Necl-1

Molecular Weight: 60.5 kDa

UniProt: Q1WIM3

Pathways: Cell-Cell Junction Organization