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CADM3 Protein (His tag)

CADM3 Origin: Rat Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Catalog No. ABIN7321187
  • Target See all CADM3 Proteins
    CADM3 (Cell Adhesion Molecule 3 (CADM3))
    Protein Type
    Recombinant
    Origin
    • 5
    • 2
    • 1
    • 1
    • 1
    Rat
    Source
    • 7
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This CADM3 protein is labelled with His tag.
    Purpose
    Recombinant Rat CADM3 Protein (His Tag)
    Sequence
    Met 1-His 328
    Characteristics
    A DNA sequence encoding the rat CADM3 (Q1WIM3) extracellular domain (Met 1-His 328) was expressed, fused with a polyhistidine tag at the C-terminus.
    Purity
    > 90 % as determined by SDS-PAGE
    Endotoxin Level
    < 1.0 EU per μg of the protein as determined by the LAL method
    Top Product
    Discover our top product CADM3 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.5
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CADM3 (Cell Adhesion Molecule 3 (CADM3))
    Alternative Name
    CADM3 (CADM3 Products)
    Synonyms
    BIgR Protein, IGSF4B Protein, NECL1 Protein, Necl-1 Protein, TSLL1 Protein, synCAM3 Protein, Igsf4b Protein, Necl1 Protein, SynCAM3 Protein, Tsll1 Protein, necl1 Protein, cell adhesion molecule 3 Protein, cell adhesion molecule 3 S homeolog Protein, CADM3 Protein, Cadm3 Protein, cadm3.S Protein
    Background

    Background: Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind (homophilic binding) or with other CAMs or the extracellular matrix (heterophilic binding). Cell adhesion molecule 3, also known as Immunoglobulin superfamily member 4B, CADM3, and NECL1, is a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule which has Ca(2+)-independent homo- or heterophilic cell-cell adhesion activity and plays an important role in the formation of synapses, axon bundles and myelinated axons. Isoform 1 of CADM3 is expressed mainly in adult and fetal brain. Isoform 2 of CADM3 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. CADM3 is involved in the cell-cell adhesion. It has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. The interaction with EPB41L1 may regulate structure or function of cell-cell junctions. CADM3 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation.

    Synonym: CADM3,Igsf4b,Necl1,Necl-1

    Molecular Weight
    35 kDa
    UniProt
    Q1WIM3
    Pathways
    Cell-Cell Junction Organization
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