Ectodysplasin A2 Receptor Protein (EDA2R) (His tag)
-
- Target See all Ectodysplasin A2 Receptor (EDA2R) Proteins
- Ectodysplasin A2 Receptor (EDA2R)
- Protein Type
- Recombinant
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Ectodysplasin A2 Receptor protein is labelled with His tag.
- Purpose
- Recombinant Human XEDAR/EDA2R Protein (His Tag)
- Sequence
- Met 1-Thr 138
- Characteristics
- A DNA sequence encoding the human EDA2R (NP_068555.1) extracellular domain (Met 1-Thr 138) fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product EDA2R Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- Target
- Ectodysplasin A2 Receptor (EDA2R)
- Alternative Name
- XEDAR/EDA2R (EDA2R Products)
- Synonyms
- EDA-A2R Protein, EDAA2R Protein, TNFRSF27 Protein, XEDAR Protein, 9430060M22Rik Protein, Xedar Protein, RGD1564025 Protein, ectodysplasin A2 receptor Protein, EDA2R Protein, Eda2r Protein
- Background
-
Background: Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).
Synonym: EDA-A2R;EDAA2R;TNFRSF27;XEDAR
- Molecular Weight
- 16.7 kDa
- NCBI Accession
- NP_068555
-