ESM1 Protein (His tag)
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- Target See all ESM1 Proteins
- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Human Cells
- Purification tag / Conjugate
- This ESM1 protein is labelled with His tag.
- Purpose
- Recombinant Mouse ESM1/Endocan Protein (Human Cells, His Tag)
- Sequence
- Trp20-Arg184
- Characteristics
- Recombinant Mouse Endothelial cell-specific molecule 1 is produced by our Mammalian expression system and the target gene encoding Trp20-Arg184 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Endothelial Cell-Specific Molecule 1 (ESM1) (AA 1-184) protein (GST tag)
ESM1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Endothelial Cell-Specific Molecule 1 (ESM1) (AA 85-184) protein (GST tag)ESM1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Endothelial Cell-Specific Molecule 1 (ESM1) protein (His tag)ESM1 Origin: Human Host: Human Cells Recombinant >90 % as determined by reducing SDS-PAGE.
Endothelial Cell-Specific Molecule 1 (ESM1) protein (His tag)ESM1 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE
Endothelial Cell-Specific Molecule 1 (ESM1) (AA 20-184) protein (His tag)Crystallography grade ESM1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Endothelial Cell-Specific Molecule 1 (ESM1) (AA 22-184) protein (His tag)Crystallography grade ESM1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
- Alternative Name
- ESM1/Endocan (ESM1 Products)
- Synonyms
- ESM1 Protein, zgc:153027 Protein, 0610042H23Rik Protein, AV004503 Protein, ESM-1 Protein, Pg25 Protein, endocan Protein, endothelial cell specific molecule 1 Protein, endothelial cell-specific molecule 1 Protein, ESM1 Protein, esm1 Protein, Esm1 Protein
- Background
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Background: Endothelial cell-specific molecule-1 (ESM-1)-so-called endocan-is a novel endothelium derived soluble dermatan sulfate proteoglycan (PG) that is constitutively expressed by endothelial cells in lungs and kidneys and can be detected in human blood. It is encoded by the ESM1 gene. The expression of this gene is regulated by several cytokines and growth factors, such as vascular endothelial growth factor. Inflammatory cytokines, such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α, stimulate the upregulation of endocan mRNA and the secretion of endocan from endothelial cells. The binding of circulating endocan to leukocyte ligand for ICAM-1-Lymphocyte Function-associated Antigen-1 (LFA-1) and to leukocyte ligand for VCAM-1-Very Late Antigen-4 (VLA-4) is important in leukocyte adhesion and interaction with activated endothelium. Endocan is a key player in the regulation of major processes such as cell adhesion in inflammatory disorders and tumor progression.
Synonym: Endothelial cell-specific molecule 1, ESM-1, Esm1, Endocan
- Molecular Weight
- 19.0 kDa
- UniProt
- Q9QYY7
- Pathways
- Growth Factor Binding
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