GLA Protein (His tag)
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- Target See all GLA Proteins
- GLA (Galactosidase, alpha (GLA))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This GLA protein is labelled with His tag.
- Purpose
- Recombinant Human Alpha-Galactosidase A/GLA Protein (His Tag)
- Sequence
- Leu32-Leu429
- Characteristics
- Recombinant Human alpha-Galactosidase is produced by our Mammalian expression system and the target gene encoding Leu32-Leu429 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product GLA Protein
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Galactosidase, alpha (GLA) (AA 1-429) protein (GST tag)
GLA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Galactosidase, alpha (GLA) (AA 322-409) protein (His-IF2DI Tag)GLA Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Galactosidase, alpha (GLA) (Active) protein (His tag)GLA Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Galactosidase, alpha (GLA) (AA 32-419) protein (His tag)Crystallography grade GLA Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- GLA (Galactosidase, alpha (GLA))
- Alternative Name
- Alpha-Galactosidase A/GLA (GLA Products)
- Synonyms
- GALA Protein, Ags Protein, zgc:101584 Protein, MGC130872 Protein, SMU.877 Protein, SCF11.21 Protein, AO090005000217 Protein, alpha-GAL Protein, galactosidase alpha Protein, galactosidase, alpha Protein, galactosidase alpha S homeolog Protein, alpha-galactosidase Protein, aga Protein, alpha-galactosidase A Protein, GLA Protein, Gla Protein, gla Protein, gla.S Protein, agaN Protein, aga Protein, agaL Protein, SCO0541 Protein, rafA Protein, melA Protein, galA Protein, ANI_1_2528074 Protein, ANI_1_1502124 Protein, AOR_1_390174 Protein, CpipJ_CPIJ002066 Protein, MCYG_00962 Protein, MCYG_00791 Protein, Tsp_02909 Protein, Tsp_02508 Protein
- Background
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Background: α-Galactosidase A is a homodimeric glycoprotein that belongs to the glycosyl hydrolase 27 family. It is a lysosomal enzyme and used as a long-term enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease. α-Galactosidase A can hydrolyze terminal α-galactosyl moieties from glycolipids and glycoproteins and catalyze the hydrolysis of melibiose into galactose and glucose. Defects α-Galactosidase A are the cause of Fabry disease (FD) which is a rare X-linked sphingolipidosis disease with glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipid catabolism. FD patients show systemic accumulation of globotriaoslyceramide (Gb3) and related glycosphingolipids in the plasma and cellular lysosomes throughout the body. Patients may show ocular deposits, febrile episodes, and burning pain in the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or other vascular disease.
Synonym: Alpha-Galactosidase A, Alpha-D-Galactosidase A, Alpha-D-Galactoside Galactohydrolase, Melibiase, Agalsidase, GLA,GLAL
- Molecular Weight
- 46.4 kDa
- UniProt
- P06280
- Pathways
- SARS-CoV-2 Protein Interactome
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