HYOU1 Protein (His tag)

Catalog No. ABIN7317574

Product Details

Target: HYOU1 (Hypoxia Up Regulated 1 (HYOU1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This HYOU1 protein is labelled with His tag.

Purpose: Recombinant Human ORP150/HSP12A Protein (His Tag)

Sequence: Met 695-Leu 994

Characteristics: A DNA sequence encoding the C-terminal segment of human HSP12A (NP_001124463.1) (Met 695-Leu 994) was expressed, fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.

Purity: > 97 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: HYOU1 (Hypoxia Up Regulated 1 (HYOU1))

Alternative Name: ORP150/HSP12A (HYOU1 Products)

Synonyms: GRP-170 Protein, Grp170 Protein, HSP12A Protein, ORP-150 Protein, ORP150 Protein, AI415631 Protein, CBP-140 Protein, Cab140 Protein, Orp150 Protein, id:ibd5056 Protein, wu:fd14c05 Protein, zgc:56019 Protein, HYOU1 Protein, orp150 Protein, GRP170 Protein, hypoxia up-regulated 1 Protein, hypoxia up-regulated protein 1 Protein, hypoxia up-regulated 1 S homeolog Protein, HYOU1 Protein, Hyou1 Protein, hyou1 Protein, LOC100380749 Protein, hyou1.S Protein

Background:

Background: Hypoxia up-regulated protein 1, also known as 150 kDa oxygen-regulated protein, 170 kDa glucose-regulated protein, ORP-150, GRP-170 and HYOU1, is a member of the heat shock protein 70 family. Seven members from four different heat shock protein (HSP) families were identified including HYOU1 (ORP150), HSPC1 (HSP86), HSPA5 (Bip), HSPD1 (HSP60), and several isoforms of the two testis-specific HSP70 chaperones HSPA2 and HSPA1L. HYOU1 is highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. It is highly expressed in liver and pancreas. HYOU1 is also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers. HYOU1 has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. It may play a role as a molecular chaperone and participate in protein folding. Suppression of HYOU1 is associated with accelerated apoptosis. It is suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness.

Synonym: Hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; ORP-150; 170 kDa glucose-regulated protein; GRP-170; HYOU1; ORP150;Grp170;HSP12A

Molecular Weight: 35.2 kDa

NCBI Accession: NP_001124463

Pathways: ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome