IL17 Receptor B Protein (Fc Tag)

Catalog No. ABIN7317311

Product Details

Target: IL17 Receptor B (IL17RB) (Interleukin 17 Receptor B (IL17RB))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This IL17 Receptor B protein is labelled with Fc Tag.

Purpose: Recombinant Human IL17BR/IL17RB Protein (Fc Tag)(Active)

Sequence: Met 1-Gly289

Characteristics: A DNA sequence encoding the human IL17BR (NP_061195.2) (Met1-Gly289) was expressed with the Fc region of human IgG1 at the C-terminus.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized human IL17BR-Fc at 10μg/mL (100μL/well) can bind biotinylated human Fc-IL25.The EC50 of human Fc-IL25 is 4.5-10.4ng/mL.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IL17 Receptor B (IL17RB) (Interleukin 17 Receptor B (IL17RB))

Alternative Name: IL17BR/IL17RB (IL17RB Products)

Synonyms: IL17RB Protein, CRL4 Protein, EVI27 Protein, IL17BR Protein, IL17RH1 Protein, Evi27 Protein, IL-17ER Protein, IL-17Rh1 Protein, Il17br Protein, interleukin 17 receptor B Protein, IL17RB Protein, Il17rb Protein

Background:

Background: R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells, consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice, they exhibited greater metastatic activity than cells derived from Wnt1 tumors.

Synonym: CRL4,EVI27,IL17BR,IL17RH1

Molecular Weight: 56.9 kDa

NCBI Accession: NP_061195