IL23R Protein (Fc Tag)
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- Target See all IL23R Proteins
- IL23R (Interleukin 23 Receptor (IL23R))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Rat
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL23R protein is labelled with Fc Tag.
- Purpose
- Recombinant Rat IL23R/IL23 Receptor Protein (Fc Tag)(Active)
- Sequence
- Met1-Asp367
- Characteristics
- A DNA sequence encoding the rat IL23R (Met1-Asp367) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
- Purity
- (75.1+16.6) as determined by SDS-PAGE
- Biological Activity Comment
- Measured by its ability to bind recombinant mouse IL12Bh (m)+mIL23Ah in a functional ELISA.
- Top Product
- Discover our top product IL23R Protein
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Interleukin 23 Receptor (IL23R) (AA 24-355) protein (mFc Tag)
IL23R Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 23 Receptor (IL23R) (AA 24-355) protein (His tag)IL23R Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 23 Receptor (IL23R) (AA 24-374) protein (His tag)IL23R Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 23 Receptor (IL23R) (AA 24-354) protein (His tag)IL23R Origin: Dog Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 23 Receptor (IL23R) (AA 24-353) protein (His tag)IL23R Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 23 Receptor (IL23R) (AA 24-355) (Active) protein (Fc Tag,AVI tag,Biotin)IL23R Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 23 Receptor (IL23R) protein (Fc Tag)IL23R Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Interleukin 23 Receptor (IL23R) (AA 553-628) protein (GST tag)IL23R Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 23 Receptor (IL23R) (AA 377-629) protein (His tag)Crystallography grade IL23R Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interleukin 23 Receptor (IL23R) (AA 396-644) protein (His tag)Crystallography grade IL23R Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- IL23R (Interleukin 23 Receptor (IL23R))
- Alternative Name
- IL23R/IL23 Receptor (IL23R Products)
- Synonyms
- IL-23R Protein, IL23R Protein, il-23r Protein, interleukin 23 receptor Protein, IL23R Protein, il23r Protein, Il23r Protein
- Background
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Background: IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.
Synonym: IL23R
- Molecular Weight
- 69.4 kDa
- NCBI Accession
- XP_003753958
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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