KIR2DL3 Protein (His tag)
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- Target See all KIR2DL3 Proteins
- KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))
- Protein Type
- Recombinant
- Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This KIR2DL3 protein is labelled with His tag.
- Purpose
- Recombinant Human KIR2DL3 Protein (His Tag)
- Sequence
- His22-His245
- Characteristics
- Recombinant Human killer cell immunoglobulin-like receptor 2DL3 is produced by our Mammalian expression system and the target gene encoding His22-His245 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product KIR2DL3 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))
- Alternative Name
- KIR2DL3 (KIR2DL3 Products)
- Synonyms
- CD158B2 Protein, CD158b Protein, GL183 Protein, KIR-023GB Protein, KIR-K7b Protein, KIR-K7c Protein, KIRCL23 Protein, NKAT Protein, NKAT2 Protein, NKAT2A Protein, NKAT2B Protein, p58 Protein, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 Protein, KIR2DL3 Protein
- Background
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Background: Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.
Synonym: Killer Cell Immunoglobulin-Like Receptor 2DL3, CD158 Antigen-Like Family Member B2, KIR-023GB, Killer Inhibitory Receptor cl 2-3, MHC Class I NK Cell Receptor, NKAT2a, NKAT2b, Natural Killer-Associated Transcript 2, NKAT-2, p58 Natural Killer Cell Receptor Clone CL-6, p58 NK Receptor CL-6, p58.2 MHC Class-I-Specific NK Receptor, CD158b2, KIR2DL3, CD158B2, KIRCL23, NKAT2,KIR-K7b,KIR-K7c,KIR2DS5,KIRCL23,MGC129943,NKAT,NKAT2,NKAT2A,NKAT2B
- Molecular Weight
- 25.4 kDa
- Pathways
- Cancer Immune Checkpoints
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