KIR2DL3 Protein (His-Avi Tag,Biotin)
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- Target See all KIR2DL3 Proteins
- KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))
- Protein Type
- Recombinant
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This KIR2DL3 protein is labelled with His-Avi Tag,Biotin.
- Sequence
- His22-His245
- Purity
- > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product KIR2DL3 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))
- Alternative Name
- KIR2DL3 (KIR2DL3 Products)
- Synonyms
- CD158B2 Protein, CD158b Protein, GL183 Protein, KIR-023GB Protein, KIR-K7b Protein, KIR-K7c Protein, KIRCL23 Protein, NKAT Protein, NKAT2 Protein, NKAT2A Protein, NKAT2B Protein, p58 Protein, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 Protein, KIR2DL3 Protein
- Background
- Cl-6, KIR2DL3, KIRCL23, KIR-K7b, KIR-K7c, MGC129943, NKAT, NKAT2, NKAT-2, NKAT2A, NK-receptor, p58, NKAT2GL183, CD158b, CD158B2, GL183, KIR-023GB, KIR2DS5, NKAT2B,KIR2DL3 (2DL3, formerly NKAT2, designated CD158b2) is a 341 amino acid (aa) type I transmembrane glycoprotein that belongs to the human killer cell Ig-like receptor (KIR) family of molecules. KIRs are expressed on human CD56dim NK cells and T cell subsets, and regulate effector functions in the innate immune system.KIR2DL3 is a receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
- Molecular Weight
- 27.3 kDa. Due to glycosylation, the protein migrates to 45-52 kDa based on Tris-Bis PAGE result.
- UniProt
- P43628
- Pathways
- Cancer Immune Checkpoints
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