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NTRK3 Protein (His tag)

NTRK3 Origin: Mouse Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7320924
  • Target See all NTRK3 Proteins
    NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
    Protein Type
    Recombinant
    Origin
    • 18
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Source
    • 10
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Human Cells
    Purification tag / Conjugate
    This NTRK3 protein is labelled with His tag.
    Purpose
    Recombinant Mouse TrkC/Ntrk3 (C-6His)
    Sequence
    Cys32-Thr429
    Characteristics
    Recombinant Mouse NT-3 Growth Factor Receptor is produced by our Mammalian expression system and the target gene encoding Cys32-Thr429 is expressed with a 6His tag at the C-terminus.
    Purity
    >95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product NTRK3 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
    Alternative Name
    TrkC/Ntrk3 (NTRK3 Products)
    Synonyms
    TRKC Protein, gp145(trkC) Protein, trkC Protein, AW125844 Protein, Ntrk3_tv3 Protein, TrkC Protein, neurotrophic receptor tyrosine kinase 3 Protein, neurotrophic tyrosine kinase, receptor, type 3 Protein, NTRK3 Protein, Ntrk3 Protein
    Background

    Background: Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT-3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC only binds NT-3. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system. Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

    Synonym: GP145-TrkC, TrkC, trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, NT-3 Growth Factor Receptor

    Molecular Weight
    45.5 kDa
    UniProt
    Q6VNS1
    Pathways
    RTK Signaling, Neurotrophin Signaling Pathway, Regulation of Cell Size
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