Poliovirus Receptor Protein (PVR) (AA 1-345) (His tag)

Catalog No. ABIN7320344

Product Details

Target: Poliovirus Receptor (PVR)

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 1-345

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This Poliovirus Receptor protein is labelled with His tag.

Purpose: Recombinant Mouse CD155/PVR Protein (aa 1-345, His Tag)(Active)

Sequence: Met 1-Arg 345

Characteristics: A DNA sequence encoding the mouse CD155 (NP_081790.1) precursor (Met 1-Arg 345) was expressed with a C-terminal polyhistidine tag.

Purity: > 97 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind recombinant mouse CD226/DNAM-1.Immobilized recombinant mouse CD155/PVR at 1 μg/ml (100 μl/well) can bind recombinant mouse CD226/DNAM-1 with a linear range of 0.78-100 ng/ml.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Poliovirus Receptor (PVR)

Alternative Name: CD155/PVR (PVR Products)

Synonyms: PVR Protein, CD155 Protein, HVED Protein, NECL5 Protein, Necl-5 Protein, PVS Protein, TAGE4 Protein, 3830421F03Rik Protein, D7Ertd458e Protein, Taa1 Protein, Tage4 Protein, mE4 Protein, necl-5 Protein, poliovirus receptor Protein, PVR Protein, Pvr Protein

Background:

Background: CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.Immune CheckpointImmune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: Poliovirus receptor; CD155 antigen; Nectin-like protein 5; Nectin-2; Tage4 receptor; Pvr; PVR; Necl5; CD155;3830421F03Rik;D7Ertd458e;HVED;mE4;necl-5;PVS;Taa1;Tage4

Molecular Weight: 28 kDa

NCBI Accession: NP_081790

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome