Prolactin Receptor Protein (PRLR) (Fc Tag)

Catalog No. ABIN7320784

Product Details

Target: Prolactin Receptor (PRLR)

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This Prolactin Receptor protein is labelled with Fc Tag.

Purpose: Recombinant Mouse PRLR/Prolactin Receptor Protein (Fc Tag)

Sequence: Gln20-Asp229

Characteristics: Recombinant Mouse Prolactin receptor is produced by our Mammalian expression system and the target gene encoding Gln20-Asp229 is expressed with a Fc tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Prolactin Receptor (PRLR)

Alternative Name: PRLR/Prolactin Receptor (PRLR Products)

Synonyms: hPRLrI Protein, PRL-R Protein, prlr Protein, PRLRb Protein, PRLR Protein, tprlr Protein, DKFZp469D061 Protein, RATPRLR Protein, AI987712 Protein, Pr-1 Protein, Pr-3 Protein, Prlr-rs1 Protein, wu:fj65c07 Protein, prolactin receptor Protein, prolactin receptor L homeolog Protein, prolactin receptor S homeolog Protein, prolactin receptor a Protein, PRLR Protein, prlr.L Protein, prlr.S Protein, PR Protein, prlr Protein, Prlr Protein, prlra Protein

Background:

Background: The prolactin receptor (PRLR) is a member of the class I cytokine/lactogen receptor family which mediates the diverse cellular actions of prolactin in several tissues. PRLRs are expressed in normal and neoplastic human breast tissue, and in most breast cancer cells. PRLR contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region required for the activation of the Jak2-Stat5 signal transduction pathway by Prl which is essential for transcriptional activation of all known prolactin regulated genes. PRLRs have also been observed in ovarian follicular cells of mice, pigs, sheep, deer, and humans, as well as in luteal tissue in cow and horse ovaries. Furthermore, PRLR knockout mice exhibit failure of embryonic implantation, reduced number of mature oocytes, and low fertilization rates. Knockout females also display a reduced number of primary follicles.

Synonym: Prolactin receptor, PRL-R, Prlr, Prolactin R, PRLR

Molecular Weight: 51.7 kDa

UniProt: Q08501

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus