PDK4 Protein (GST tag,His tag)
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- Target See all PDK4 Proteins
- PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This PDK4 protein is labelled with GST tag,His tag.
- Purpose
- Recombinant Mouse PDK4 Protein (His & GST Tag)(Active)
- Sequence
- Met1-Val412
- Characteristics
- A DNA sequence encoding the mouse PDK4 (O70571) (Met1-Val412) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- Purity
- > 85 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Kinase activity untested
- Top Product
- Discover our top product PDK4 Protein
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))
- Alternative Name
- PDK4 (PDK4 Products)
- Synonyms
- AV005916 Protein, pyruvate dehydrogenase kinase 4 Protein, pyruvate dehydrogenase kinase, isoenzyme 4 Protein, pdk4 Protein, PDK4 Protein, Pdk4 Protein
- Background
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Background: Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability.Pyruvate dehydrogenase kinase 4 (PDK4) mRNA has been reported as an up-regulated gene in the heart and skeletal muscle of carnitine-deficient juvenile visceral steatosis (JVS) mice under fed conditions. PDK4 plays an important role in the inhibition of glucose oxidation via the phosphorylation of pyruvate dehydrogenase complex (PDC).PDK4 gene expression is stimulated by thyroid hormone (T(3)), glucocorticoids, and long chain fatty acids.
Synonym: AV005916
- Molecular Weight
- 74.4 kDa
- UniProt
- O70571
- Pathways
- PI3K-Akt Signaling, Hedgehog Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect
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