SCARB1 Protein (His tag,Fc Tag)

Catalog No. ABIN7197833

Product Details

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This SCARB1 protein is labelled with His tag,Fc Tag.

Purpose: Recombinant Human SR-BI/CD36L1 Protein (His & Fc Tag)(Active)

Sequence: Pro 33-Tyr 443

Characteristics: A DNA sequence encoding the human SCARB1 (NP_005496.4) extracellular domain (Pro 33-Tyr 443) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Purity: > 98 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: 1. Measured by its ability to bind recombinant mouse ApoAI in a functional ELISA.2. Measured by its ability to bind recombinant Human ApoAI in a functional ELISA.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Alternative Name: SR-BI/CD36L1 (SCARB1 Products)

Synonyms: cb1015 Protein, SCARB1 Protein, Scarb1 Protein, CD36L1 Protein, CLA-1 Protein, CLA1 Protein, HDLQTL6 Protein, SR-BI Protein, SRB1 Protein, AI120173 Protein, CD36 Protein, Cd36l1 Protein, Cla-1 Protein, Cla1 Protein, D5Ertd460e Protein, Hdlq1 Protein, Hlb398 Protein, SR-B1 Protein, SRBI Protein, Srb1 Protein, mSR-BI Protein, scavenger receptor class B, member 1 Protein, scavenger receptor class B member 1 Protein, scarb1 Protein, SCARB1 Protein, Scarb1 Protein, CpipJ_CPIJ014332 Protein, CpipJ_CPIJ019101 Protein

Background:

Background: Scavenger receptor class B; member 1 (SCARB1); also known as CD36L1; is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues; and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids; cholesterol ester; lipoproteins; phosphatidylserine and apoptotic cells; and is involved in a wide variety of physilogical processes. As a key component in the reverse cholesterol transport pathway; SCARB1 binds high density lipoproteins (HDLs) and mediates selective cholesterol uptake by a mechanism distinct from the LDL pathway. High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SCARB1 may thus serve as a useful marker that predicts variation in baseline lipid levels and postprandial lipid response. The mouse SCARB1 has been shown to exert actions in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.

Synonym: CD36L1;CLA-1;CLA1;HDLQTL6;SR-BI;SRB1

Molecular Weight: 78 kDa

NCBI Accession: NP_005496

Pathways: Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Lipid Metabolism, SARS-CoV-2 Protein Interactome