SERPINB3 Protein (His tag)

Catalog No. ABIN7320213

Product Details

Target: SERPINB3 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3))

Protein Type: Recombinant

Origin: Mouse

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This SERPINB3 protein is labelled with His tag.

Purpose: Recombinant Mouse SerpinB3/SCCA1 Protein (His Tag)

Sequence: Met 1-Pro 386

Characteristics: A DNA sequence encoding the mouse SERPINB3C (NP_958751.2) (Met 1-Pro 386) was expressed, with a C-terminal polyhistidine tag.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris 100 mM NaCl, pH 8.0

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SERPINB3 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3))

Alternative Name: SerpinB3/SCCA1 (SERPINB3 Products)

Synonyms: HsT1196 Protein, SCC Protein, SCCA-1 Protein, SCCA-PD Protein, SCCA1 Protein, T4-A Protein, LEUPIN Protein, PI11 Protein, SCCA-2 Protein, SCCA2 Protein, serpin family B member 3 Protein, serpin family B member 4 Protein, serpin B3 Protein, Somatic cell count Protein, SERPINB3 Protein, SERPINB4 Protein, Serpinb3 Protein, LOC483954 Protein, SCC Protein

Background:

Background: Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1000 serpins have been identified. Mouse SerpinB3, also known as Squamous cell carcinoma antigen 1, SCCA-1, SERPINB3, SCCA and SCCA1, is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. SerpinB3 may act as a protease inhibitor to modulate the host immune response against tumor cells. Mouse SerpinB3a and SerpinB3b, but not Serpinb3c, are functional, inhibiting both serine and cysteine proteinases with different inhibitory profiles due to the difference of two amino acids in their reactive site loops. SerpinB3a is ubiquitously expressed in most tissues, whereas expression of SerpinB3b is limited to keratinocytes. SerpinB3a and SerpinB3b may play different roles by inhibiting intrinsic or extrinsic proteinases with different expression distributions and different inhibitory profiles.

Synonym: 1110001H02Rik;1110013A16Rik;Scca2;Serpinb3c;Serpinb4

Molecular Weight: 46.5 kDa

NCBI Accession: NP_958751