SERPIND1 Protein (His tag)
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- Target See all SERPIND1 Proteins
- SERPIND1 (serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Human Cells
- Purification tag / Conjugate
- This SERPIND1 protein is labelled with His tag.
- Purpose
- Recombinant Mouse SerpinD1/HCF2 Protein (His Tag)
- Sequence
- Glu24-Ser478
- Characteristics
- Recombinant Mouse Serine Protease Inhibitor-clade D1 is produced by our Mammalian expression system and the target gene encoding Glu24-Ser478 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product SERPIND1 Protein
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serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) (AA 1-499) protein (GST tag)
SERPIND1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) (Active) protein (His tag)SERPIND1 Origin: Mouse Host: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) (AA 20-499) protein (His tag)Crystallography grade SERPIND1 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) (AA 24-478) protein (His tag)Crystallography grade SERPIND1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM HEPES,150 mM NaCl, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- SERPIND1 (serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1))
- Alternative Name
- SerpinD1/HCF2 (SERPIND1 Products)
- Synonyms
- D22S673 Protein, HC2 Protein, HCF2 Protein, HCII Protein, HLS2 Protein, LS2 Protein, THPH10 Protein, serpind1 Protein, MGC53936 Protein, rls2var1 Protein, AA985900 Protein, AI303446 Protein, Hcf2 Protein, serpin family D member 1 Protein, serpin peptidase inhibitor, clade D (heparin cofactor), member 1 L homeolog Protein, serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Protein, serine (or cysteine) peptidase inhibitor, clade D, member 1 Protein, SERPIND1 Protein, serpind1.L Protein, Serpind1 Protein, serpind1 Protein
- Background
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Background: SerpinD1, also known as heparin cofactor II(HC-II), is a member of Serpin superfamily of the serine proteinase inhibitors. It is a single chain glycoprotein with a size of 66.5 kDa and is secreted from hepatocytes. HC-II acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. It has been suggested that HC-II is a predictor of decreased atherosclerosis in the elderly and protective against atherosclerosis in mice. HCII can used as a predictive biomarker and therapeutic target for atherosclerosis.
Synonym: Heparin cofactor 2, Heparin cofactor II, HC-II, Protease inhibitor leuserpin-2, Serpin D1
- Molecular Weight
- 53.1 kDa
- UniProt
- P49182
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