Quick Overview for TNFRSF18 Protein (His tag,Fc Tag) (ABIN7320534)
Target
See all TNFRSF18 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purification tag / Conjugate
- This TNFRSF18 protein is labelled with His tag,Fc Tag.
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Purpose
- Recombinant Mouse GITR/TNFRSF18 Protein (Fc & His Tag)(Active)
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Sequence
- Ser22-His153
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Characteristics
- Recombinant Mouse Glucocorticoid Induced TNF Receptor Family Related Gene is produced by our Mammalian expression system and the target gene encoding Ser22-His153 is expressed with a Fc, 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- Immobilized Human GITRL-His(Cat: PKSH032485) at 10μg/ml(100 μl/well) can bind Mouse GITR -Fc-His.
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Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-161) (Active) protein (His tag)
TNFRSF18 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 20-156) (Active) protein (His tag)TNFRSF18 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-161) (Active) protein (Biotin,His-Avi Tag)TNFRSF18 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 22-153) (Active) protein (His tag)TNFRSF18 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-162) protein (His tag,mFc Tag)TNFRSF18 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-162) protein (His tag,Fc Tag)TNFRSF18 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 1-241) protein (GST tag)TNFRSF18 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-115) protein (GST tag)TNFRSF18 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 22-153) protein (Fc Tag)TNFRSF18 Origin: Mouse Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-162) protein (hIgG-His-tag)TNFRSF18 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
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Alternative Name
- GITR/TNFRSF18
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Background
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Background: Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA, isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
Synonym: Tumor necrosis factor receptor superfamily member 18,Glucocorticoid-induced TNFR-related protein,Tnfrsf18, AITR,CD357,GITR-D,TNFRSF18
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Molecular Weight
- 41.12 kDa
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UniProt
- O35714
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Pathways
- Cancer Immune Checkpoints
Target
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