IL17RA Protein (AA 33-320) (His tag)

Catalog No. ABIN7274223

Product Details

Target: IL17RA (Interleukin 17 Receptor A (IL17RA))

Protein Type: Recombinant

Protein Characteristics: AA 33-320

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This IL17RA protein is labelled with His tag.

Purpose: Human IL-17R alpha/CD217 Protein

Sequence: Leu33-Trp320

Characteristics: Recombinant Human IL-17R alpha/CD217 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu33-Trp320.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Biological Activity Comment: The affinity constant of 1.57 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: IL17RA (Interleukin 17 Receptor A (IL17RA))

Alternative Name: IL-17R alpha (IL17RA Products)

Synonyms: IL17R Protein, CANDF5 Protein, CD217 Protein, CDw217 Protein, IL-17RA Protein, hIL-17R Protein, Il17r Protein, AW538159 Protein, Cdw217 Protein, VDw217 Protein, interleukin 17 receptor A Protein, IL17RA Protein, Il17ra Protein

Background: Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleotropic cytokine. IL-17 binds to IL-17 receptor (IL-17 R) which shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL-17 R gene was localized to chromosome 22.

Molecular Weight: 34.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.

Pathways: SARS-CoV-2 Protein Interactome