Desmoglein 2 Protein (DSG2) (AA 50-609) (His tag)
DSG2
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Target See all Desmoglein 2 (DSG2) Proteins
- Desmoglein 2 (DSG2)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 50-609
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Desmoglein 2 protein is labelled with His tag.
- Purpose
- Human DSG-2/Desmoglein-2 Protein
- Sequence
- Ala50-Gly609
- Characteristics
- Recombinant Human DSG-2/Desmoglein-2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala50-Gly609.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human DSG-2, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-DSG-2 Antibody, hFc Tag with the EC50 of 0.17ug/ml determined by ELISA. See testing image for detail.
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Desmoglein 2 (DSG2) (AA 55-618) protein (His tag)
DSG2 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Desmoglein 2 (DSG2)
- Alternative Name
- DSG-2 (DSG2 Products)
- Synonyms
- DSG2 Protein, dsc Protein, dsga Protein, si:dkeyp-51f12.6 Protein, wu:fj23f02 Protein, ARVC10 Protein, ARVD10 Protein, CDHF5 Protein, CMD1BB Protein, HDGC Protein, AA408168 Protein, D18Ertd293e Protein, desmoglein 2 Protein, desmoglein 2, tandem duplicate 1 Protein, DSG2 Protein, dsg2.1 Protein, dsg2 Protein, Dsg2 Protein
- Background
- Desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions.
- Molecular Weight
- 63.6 kDa. Due to glycosylation, the protein migrates to 75-80 kDa based on Tris-Bis PAGE result.
- UniProt
- Q14126
- Pathways
- Cell-Cell Junction Organization
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