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WFDC1 Protein (AA 32-192) (His tag)

WFDC1 Origin: Cynomolgus Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Catalog No. ABIN7275482
  • Target See all WFDC1 Proteins
    WFDC1 (WAP Four-Disulfide Core Domain 1 (WFDC1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 32-192
    Origin
    • 4
    • 3
    • 3
    • 1
    Cynomolgus
    Source
    • 5
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This WFDC1 protein is labelled with His tag.
    Purpose
    Cynomolgus PS20 Protein
    Sequence
    Lys32-Gln192
    Characteristics
    Recombinant Cynomolgus PS20 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Lys32-Gln192.
    Purity
    > 95 % as determined by Tris-Bis PAGE
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1EU per μg by the LAL method.
    Top Product
    Discover our top product WFDC1 Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Supplied as 0.22μm filtered solution in 20 mM PB, 500 mM NaCl ( pH 7.4).
    Storage
    -80 °C
    Storage Comment
    Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    WFDC1 (WAP Four-Disulfide Core Domain 1 (WFDC1))
    Alternative Name
    PS20 (WFDC1 Products)
    Synonyms
    WFDC1 Protein, zgc:158671 Protein, PS20 Protein, 2310058A03Rik Protein, ps20 Protein, WAP four-disulfide core domain 1 Protein, WFDC1 Protein, wfdc1 Protein, Wfdc1 Protein
    Background
    The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection. Herein we describe a contrasting role for ps20 in limiting MHV-1 infection. Intranasal MHV-1 infection produces a respiratory infection in mice. Using ps20 knockout mice we provide evidence that intranasal MHV-1 infection results in increased lung viral titers in ps20(-/-) compared to ps20(/) mice. Roles for ps20 in regulating expression of neutrophil-specific chemotactic factors, thereby potentially modulating neutrophil migration, and in modulating neutrophil susceptibility to MHV-1 infection.
    Molecular Weight
    18.77 kDa. The protein migrates to 25-28 kDa based on Tris-Bis PAGE result.
    NCBI Accession
    XP_015298715
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