Claudin 18.2 protein (His tag,Strep Tag)
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- Target
- Claudin 18.2
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Insect Cells
- Purification tag / Conjugate
- His tag,Strep Tag
- Purpose
- Human Claudin-18.2 Protein, His,Twin-Strep Tag (Nanodisc)
- Sequence
- Met 1 - Ala 200
- Characteristics
- Human Claudin-18.2, His,Twin-Strep Tag is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 200 (Accession # P56856-2).
- Endotoxin Level
- 1.0 EU per μg
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Claudin 18.2 (AA 1-261) (Active) protein-VLP
Origin: Human Host: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Func, Imm, SPR Active
Claudin 18.2 (AA 1-261) (Active) protein-VLP (Biotin)Origin: Human Host: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Func, Imm, SPR Active
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- Comment
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This protein carries a polyhistidine tag at the N-terminus and a twin strep tag at the C-terminus. The protein has a calculated MW of 26.5 kDa.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 20 mM HEPES, 150 mM NaCl, pH 7.5
- Storage
- -80 °C
- Storage Comment
- -70°C
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- Target
- Claudin 18.2
- Alternative Name
- Claudin-18.2
- Background
- Synonyms:Claudin-18.2,CLDN18,Claudin-18,Description:Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
- Molecular Weight
- 26.5 kDa
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