CCR6 Protein

Catalog No. ABIN7491566

Product Details

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Protein Type: Synthetic

Origin: Human

Source: HEK-293 Cells

Purpose: Human CCR6 full length protein-synthetic nanodisc

Characteristics: Full Length Transmembrane Proteins (synthetic Nanodisc)

Application Details

Application Notes:

• Applications for VLPs:
• ELISA
• SPR affinity analysis
• Phage display screening
• Immunization
• Cell based assays
• CAR-T cell screening
• Protein cystal structure analysis

Comment:

Synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Alternative Name: CCR6 (CCR6 Products)

Synonyms: BN-1 Protein, C-C CKR-6 Protein, CC-CKR-6 Protein, CCR-6 Protein, CD196 Protein, CKR-L3 Protein, CKRL3 Protein, CMKBR6 Protein, DCR2 Protein, DRY6 Protein, GPR29 Protein, GPRCY4 Protein, STRL22 Protein, Cmkbr6 Protein, KY411 Protein, C-C motif chemokine receptor 6 Protein, chemokine (C-C motif) receptor 6 Protein, CCR6 Protein, Ccr6 Protein

Background: BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
Description: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Molecular Weight: The human full length CCR6 protein has a MW of 42.3 kDa

UniProt: P51684

Pathways: cAMP Metabolic Process