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FFAR1 Protein

FFAR1 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Catalog No. ABIN7491641
  • Target See all FFAR1 Proteins
    FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))
    Protein Type
    Synthetic Nanodisc
    Origin
    • 3
    • 2
    • 1
    Human
    Source
    • 4
    • 2
    HEK-293 Cells
    Purpose
    Human FFAR1 full length protein-synthetic nanodisc
    Characteristics
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
  • Comment

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))
    Alternative Name
    FFAR1 (FFAR1 Products)
    Synonyms
    FFAR1 Protein, GPR40 Protein, FFA1R Protein, GPCR40 Protein, Gpr40 Protein, free fatty acid receptor 1 Protein, FFAR1 Protein, Ffar1 Protein
    Background
    A member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes.
    Molecular Weight
    The human full length FFAR1 protein has a MW of 31.5 kDa
    UniProt
    O14842
    Pathways
    Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Carbohydrate Homeostasis
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