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IL-21 Protein (AA 1-154) (His tag)

IL21 Origin: Rabbit Host: HEK-293 Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505764
  • Target See all IL-21 (IL21) Proteins
    IL-21 (IL21) (Interleukin 21 (IL21))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-154
    Origin
    • 32
    • 9
    • 6
    • 2
    • 1
    • 1
    • 1
    Rabbit
    Source
    • 24
    • 15
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This IL-21 protein is labelled with His tag.
    Sequence
    Met1-Leu154
    Characteristics
    A DNA sequence encoding theRabbit IL21 protein (G1T948) (Met1-Leu154) was expressed with a C-His.
    Purity
    >95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product IL21 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Expiry Date
    12 months
  • Target
    IL-21 (IL21) (Interleukin 21 (IL21))
    Alternative Name
    IL21 (IL21 Products)
    Synonyms
    IL-21 Protein, Za11 Protein, interleukin 21 Protein, IL21 Protein, Il21 Protein
    Background

    Background: IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).

    Synonym: Interleukin-21,IL 21,IL-21

    Molecular Weight
    14.3 kDa
    UniProt
    G1T948
    Pathways
    JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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