IL-21 Protein (AA 1-154) (His tag)
-
- Target See all IL-21 (IL21) Proteins
- IL-21 (IL21) (Interleukin 21 (IL21))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-154
-
Origin
- Rabbit
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL-21 protein is labelled with His tag.
- Sequence
- Met1-Leu154
- Characteristics
- A DNA sequence encoding theRabbit IL21 protein (G1T948) (Met1-Leu154) was expressed with a C-His.
- Purity
- >95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product IL21 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
-
- Target
- IL-21 (IL21) (Interleukin 21 (IL21))
- Alternative Name
- IL21 (IL21 Products)
- Synonyms
- IL-21 Protein, Za11 Protein, interleukin 21 Protein, IL21 Protein, Il21 Protein
- Background
-
Background: IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).
Synonym: Interleukin-21,IL 21,IL-21
- Molecular Weight
- 14.3 kDa
- UniProt
- G1T948
- Pathways
- JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
-