Activin A Receptor Type IB/ALK-4 Protein (Fc Tag)

Catalog No. ABIN7536570

Product Details

Target: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This Activin A Receptor Type IB/ALK-4 protein is labelled with Fc Tag.

Purpose: Recombinant Mouse ALK-4/ACVR1B Protein

Sequence: MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QTNYTCETDG ACMVSIFNLD GVEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYIDF CNKIDLRVPS GHLKEPAHPS MWGPVE

Specificity: Met1-Glu126

Purity: > 92 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: < 0.01EU/μg

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Concentration: 0.87 mg/mL

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Target Details

Target: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Alternative Name: ALK-4/ACVR1B (ACVR1B Products)

Synonyms: ACVR1B Protein, alk4 Protein, skr2 Protein, alk-4 Protein, xalk4 Protein, actrib Protein, acvrlk4 Protein, DKFZp469A1614 Protein, 6820432J04 Protein, ActR-IB Protein, ActRIB Protein, Acvrlk4 Protein, Alk4 Protein, SKR2 Protein, ACTRIB Protein, ACVRLK4 Protein, ALK4 Protein, Skr2 Protein, axis Protein, taram-a Protein, tarama Protein, wu:fb75f01 Protein, activin A receptor type 1B Protein, Activin receptor type-1B Protein, activin A receptor, type IB Protein, activin A receptor, type 1B Protein, activin A receptor type 1Ba Protein, ACVR1B Protein, acvr1b Protein, acv1b Protein, Acvr1b Protein, acvr1ba Protein

Background:

Description: ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.

Name: Alk4, SKR2, ALK-4, ActRIB, ActR-IB, Acvrlk4, 6820432J04

Gene ID: 11479

UniProt: Q61271