CA9 Protein (His tag)

Catalog No. ABIN7535681

Product Details

Target: CA9 (Carbonic Anhydrase IX (CA9))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This CA9 protein is labelled with His tag.

Purpose: Active Recombinant Mouse Carbonic Anhydrase IX/CA9 Protein

Sequence: QPQGLSGMQG EPSLGDSSSG EDELGVDVLP SEEDAPEEAD PPDGEDPPEV NSEDRMEESL GLEDLSTPEA PEHSQGSHGD EKGGGHSHWS YGGTLLWPQV SPACAGRFQS PVDIRLERTA FCRTLQPLEL LGYELQPLPE LSLSNNGHTV QLTLPPGLKM ALGPGQEYRA LQLHLHWGTS DHPGSEHTVN GHRFPAEIHV VHLSTAFSEL HEALGRPGGL AVLAAFLQES PEENSAYEQL LSHLEEISEE GSKIEIPGLD VSALLPSDLS RYYRYEGSLT TPPCSQGVIW TVFNETVKLS AKQLHTLSVS LWGPRDSRLQ LNFRATQPLN GRTIEASFPA AEDSSPEPVH VNSCFTAGD

Specificity: Gln32-Asp390

Purity: > 95 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: <0.1EU/μg

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Target Details

Target: CA9 (Carbonic Anhydrase IX (CA9))

Alternative Name: Carbonic Anhydrase IX/CA9 (CA9 Products)

Synonyms: CA9 Protein, CAIX Protein, Ca9 Protein, MN/CA9 Protein, MN Protein, carbonic anhydrase 9 Protein, CA9 Protein, CAH9 Protein, Car9 Protein

Background:

Description: Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3-) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.

Name: CAIX,CA9,CA-IX,G250,MN,P54,58N,pMW1,CA9

Gene ID: 230099

UniProt: Q8VHB5