IL18R1 Protein (Fc Tag,His tag)

Catalog No. ABIN7533932

Product Details

Target: IL18R1 (Interleukin 18 Receptor 1 (IL18R1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This IL18R1 protein is labelled with Fc Tag,His tag.

Purpose: Active Recombinant Human IL-18R1/CD218a Protein

Sequence: ESCTSRPHIT VVEGEPFYLK HCSCSLAHEI ETTTKSWYKS SGSQEHVELN PRSSSRIALH DCVLEFWPVE LNDTGSYFFQ MKNYTQKWKL NVIRRNKHSC FTERQVTSKI VEVKKFFQIT CENSYYQTLV NSTSLYKNCK KLLLENNKNP TIKKNAEFED QGYYSCVHFL HHNGKLFNIT KTFNITIVED RSNIVPVLLG PKLNHVAVEL GKNVRLNCSA LLNEEDVIYW MFGEENGSDP NIHEEKEMRI MTPEGKWHAS KVLRIENIGE SNLNVLYNCT VASTGGTDTK SFILVRKADM ADIPGHVFTR

Specificity: Glu20-Arg329

Purity: > 85 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA.Immobilized IL18R1 Mouse mAb at 1μg/mL (100 μL/well) can bind Human IL18R1 with a linear range of 0.03-1.06ng/ml.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Target Details

Target: IL18R1 (Interleukin 18 Receptor 1 (IL18R1))

Alternative Name: IL-18R1/CD218a (IL18R1 Products)

Synonyms: CD218a Protein, CDw218a Protein, IL-1Rrp Protein, IL18RA Protein, IL1RRP Protein, IL-1R9 Protein, IL1R9 Protein, IL1RAPL-2 Protein, TIGIRR-1 Protein, Il18ralpha Protein, Il1rrp Protein, IL-18Ra Protein, IL18R1 Protein, interleukin 18 receptor 1 Protein, interleukin 1 receptor accessory protein like 2 Protein, IL18R1 Protein, IL1RAPL2 Protein, Il18r1 Protein

Background:

Description: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Name: IL18R1,CD218a,CDw218a,IL-1Rrp,IL18RA,IL1RRP,IL18R1/IL-18 R alpha

Gene ID: 8809

UniProt: Q13478