IL-1 beta Protein
-
- Target See all IL-1 beta (IL1B) Proteins
- IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
- Protein Type
- Recombinant
- Biological Activity
- Active
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Sequence
- APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
- Characteristics
-
Purified recombinant Human IL1 beta protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Mouse D10S cells is ? 1.0 pg/mL, corresponding to a specific activity of ? 1 x 10^9 units/mg. - Purity
- > 98 % pure
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
- Top Product
- Discover our top product IL1B Protein
-
Interleukin 1, beta (IL1B) (AA 117-269) protein (His-Avi Tag)
IL1B Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
Interleukin 1, beta (IL1B) (AA 117-269) protein (His-Avi Tag,Biotin)IL1B Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 1, beta (IL1B) (AA 1-269) protein (GST tag)IL1B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 1, beta (IL1B) (AA 115-267) protein (His tag)IL1B Origin: Pig Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 1, beta (IL1B) (AA 116-268) protein (His tag)IL1B Origin: Horse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 1, beta (IL1B) (AA 114-266) protein (His tag)IL1B Origin: Goat Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 1, beta (IL1B) (AA 115-266) protein (His tag)IL1B Origin: Dog Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 1, beta (IL1B) (AA 106-267) protein (His tag)IL1B Origin: Chicken Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 1, beta (IL1B) (AA 113-271) protein (His tag)IL1B Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
Interleukin 1, beta (IL1B) (AA 170-269) protein (GST tag)IL1B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Reconstitute in water to a concentration of 0.1-1.0 mg/mL. When dissolved, dilute further into aqueous buffered solutions.
- Buffer
- Sterile filtered through a 0.2 µm filter. Lyophilized from 10 mM Tris, pH 8.2.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- RT/-20 °C
-
- Target
- IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
- Alternative Name
- IL1 beta (IL1B Products)
- Synonyms
- IL-1 Protein, IL1-BETA Protein, IL1F2 Protein, IL-1BETA Protein, IL1beta Protein, il1-b Protein, zgc:111873 Protein, IL-1B Protein, IL-1beta Protein, Il-1b Protein, IL1B Protein, IL-1 beta Protein, IL-1b Protein, interleukin 1 beta Protein, interleukin 1, beta Protein, IL1B Protein, il1b Protein, Il1b Protein
- Background
-
IL1beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL2 release, B-cell maturation and proliferation, mitogenic FGFlike activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL1beta is a secreted cytokine, IL1a is predominantly a cell-associated cytokine.
Alternative Names: LAF protein, IL-1 beta protein, IL 1, Leukocyte Endogenous Mediator protein, IL-1 protein, Catabolin protein, IL-1, Lymphocyte-activating factor protein, EP protein, Mononuclear Cell Factor protein, Endogenous Pyrogen protein, Interleukin 1 beta protein, LEM protein, IL 1 protein, IL1, MCF protein - Molecular Weight
- 17.3 kDa
- Pathways
- NF-kappaB Signaling, Interferon-gamma Pathway, TLR Signaling, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome
-
