IL-1 beta Protein
Quick Overview for IL-1 beta Protein (ABIN935526)
Target
See all IL-1 beta (IL1B) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MVPIRQLHCR LRDEQQKCLV LSDPCELKAL HLNGQNISQQ VVFSMSFVQG ETSNDKIPVA LGLKGLNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKTK VEFESAQFPN WYISTSQAEH RPVFLGNSNG RDIVDFTMEP VSS
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Characteristics
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Purified recombinant Human IL1 beta protein
Expression System: E.coli
Bioactivity: The ED50 was determined by the dose-dependent stimulation of Mouse D10S cells is 1 x 10^7 units/mg. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Interleukin 1, beta (IL1B) (AA 117-269) protein (His-Avi Tag)
IL1B Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
Interleukin 1, beta (IL1B) (AA 117-269) (Active) protein (Biotin,His-Avi Tag)IL1B Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 1, beta (IL1B) (AA 1-269) protein (GST tag)IL1B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Interleukin 1, beta (IL1B) (AA 117-269) protein (Fc Tag)IL1B Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Interleukin 1, beta (IL1B) (AA 170-269) protein (GST tag)IL1B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Interleukin 1, beta (IL1B) (AA 117-269) (Active) protein (His tag)IL1B Origin: Human Host: Escherichia coli (E. coli) Recombinant >90 % as determined by SDS-PAGE. WB, SDS, Imm, ELISA, AcA Active
Interleukin 1, beta (IL1B) (AA 118-269) (Active) protein (His tag)IL1B Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >90 % as determined by SDS-PAGE. WB, SDS, Imm, ELISA, AcA Active
Interleukin 1, beta (IL1B) (Active) proteinIL1B Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 97 % as determined by SDS-PAGE Active
Interleukin 1, beta (IL1B) (Active) proteinIL1B Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 98 % as determined by SDS-PAGE Active
Interleukin 1, beta (IL1B) (AA 106-267) protein (His tag)IL1B Origin: Chicken Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute in water to a concentration of 0.1-1.0 mg/mL. When dissolved, dilute further into aqueous buffered solutions.
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Buffer
- Lyophilized from 10 mM NaC2H3O2, pH 6.5.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
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Alternative Name
- IL1 beta
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Background
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IL1beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL2 release, B-cell maturation and proliferation, mitogenic FGFlike activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells.
Alternative Names: IL 1 protein, EP protein, IL-1 protein, MCF protein, IL1, LAF protein, Leukocyte Endogenous Mediator protein, IL-1 beta protein, Interleukin 1 beta protein, Endogenous Pyrogen protein, IL 1, Mononuclear Cell Factor protein, Catabolin protein, Lymphocyte-activating factor protein, IL-1, LEM protein -
Molecular Weight
- 17.3 kDa
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Pathways
- NF-kappaB Signaling, Interferon-gamma Pathway, TLR Signaling, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome
Target
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