TNFRSF1A Protein

Catalog No. ABIN935851

Product Details

Target: TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Sequence: MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN

Characteristics: Purified recombinant Human TNF Receptor Type I protein
Expression System: E.coli
Bioactivity: Determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in Mouse L-929 cells. The ED50 for this effect in the presence of 0.25 ng/mL of recombinant human TNF-alpha, is 0.05 µg/mL.

Purity: > 97 % pure

Endotoxin Level: < 0.1 ng per µg (1 EU/µg).

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Target Details

Target: TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))

Alternative Name: TNF Receptor Type I (TNFRSF1A Products)

Synonyms: CD120a Protein, FPF Protein, MS5 Protein, TBP1 Protein, TNF-R Protein, TNF-R-I Protein, TNF-R55 Protein, TNFAR Protein, TNFR1 Protein, TNFR1-d2 Protein, TNFR55 Protein, TNFR60 Protein, p55 Protein, p55-R Protein, p60 Protein, TNF-R1 Protein, TNF-alphaR1 Protein, TNFRI Protein, TNFRp55 Protein, TNFalpha-R1 Protein, Tnfr-2 Protein, Tnfr1 Protein, fpf Protein, tbp1 Protein, p55-r Protein, tnf-r Protein, tnfar Protein, tnfr1 Protein, cd120a Protein, tnfr55 Protein, tnfr60 Protein, xtnfr1 Protein, wu:fj65b10 Protein, zgc:85914 Protein, TNFR I Protein, TNFRSF1A Protein, TNFA Protein, cTNF Protein, TNF receptor superfamily member 1A Protein, tumor necrosis factor receptor superfamily, member 1a Protein, TNF receptor superfamily member 1A S homeolog Protein, tumor necrosis factor Protein, TNFRSF1A Protein, Tnfrsf1a Protein, tnfrsf1a.S Protein, tnfrsf1a Protein, TNF Protein

Background: TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NF kb, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-alpha and TNF-beta activities by acting as a decoy receptor that serves as a sink for the TNF ligands.
Alternative Names: TNFR60 protein, TNF-R55 protein, TNF Receptor 1 protein, TNF Receptor I protein, CD120a protein, TNFRSF1A protein, p55 protein, TNFAR protein, Soluble Tumor Necrosis Factor type I protein

Molecular Weight: 18.3 kDa

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C, Ubiquitin Proteasome Pathway