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This study showed that Ndel1 Maintain Postnatal CA1 (show CA1 Proteins) Hippocampus Integrity in mice.
Data indicate that NDEL1 is inducibly expressed in the adult nervous system, and signaling via the CREB (show CREB1 Proteins)/CRE transcriptional pathway is likely involved. Role of NDEL1 in neuronal migration and neurite outgrowth during development raises the interesting prospect that inducible NDEL1 in the mature nervous system could contribute to the well-characterized structural and functional plasticity resulting from repetitive seizures
NDEL1 facilitates the reversal of somatodendritic traansport in the proximal axon.
study provided comprehensive documentation of the expression patterns of Nde1 and Ndel1 in cultured cells as well as in mouse and human brains, and also highlighting that dosage effects of these two proteins might contribute to some cases of mental disorder
Results suggest that NDEL1 might interact with DISC1 (show DISC1 Proteins) to activate ERK (show EPHB2 Proteins) signaling and function as a potential protective factor during the spontaneous seizure period after pilocarpine-induced status epilepticus
Results show that LIS1 (show PAFAH1B1 Proteins) acts via the LIS1 (show PAFAH1B1 Proteins)-NDEL1-dynein complex to regulate astral microtubule MT plus-ends dynamics and establish proper contacts of MTs (show NEU2 Proteins) with the cell cortex to ensure precise cell division.
Nuclear distribution element-like 1 (Ndel1 or Nudel) was firstly described as a regulator of the cytoskeleton in microtubule and intermediate filament dynamics and microtubule-based transport.
Expressing a mutant Ndel1 lacking key phosphorylation sites shuts down organelle transport completely in axons.
palmitoylated Ndel1 reduced cytoplasmic dynein (show DYNC1H1 Proteins) activity as judged by Golgi distribution, VSVG and short microtubule trafficking, transport of endogenous Ndel1 and LIS1 (show PAFAH1B1 Proteins) from neurite tips to the cell body and neuronal migration
Lis1 (show PAFAH1B1 Proteins) and Ndel1 are essential for normal cortical neuronal migration, neurite outgrowth, and function of the microtubule organizing center in a dose-dependent manner.
disrupting DISC1 (show DISC1 Proteins)/Ndel1 complex formation prolongs mitotic length and interferes with cell-cycle progression in human cells, and it causes cell-cycle deficits of radial glial cells in the embryonic mouse cortex and human forebrain organoids
Study showed that Ndel1 enzyme activity is a complex trait influenced by many different genetic variants that may contribute to schizophrenia physiopathology
This study observed a significantly increased myelin basic protein (MBP (show MBP Proteins)) and nuclear distribution protein nudE-like 1 (NDEL1) mRNA levels in FEP patients compared with controls.
The Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia.
Short (DISC)1 splice variants show reduced or no binding to nudE nuclear distribution E homolog (NDEL)1 and phosphodiesterase (PDE)4B proteins, but fully interact with FEZ1 and glycogen synthase kinase 3 (GSK3)beta.
Nudel markedly promotes the HSPC300 (show BRK1 Proteins)-WAVE2 (show WASF2 Proteins) interaction.
analysis of mixed NDE1-NDEL1 complexes demonstrates that NDE1 and NDEL1 can interact directly.
Cytosolic mfGbeta is recruited to dynein by Nudel and transported to the centrosome for rapid sequestration and degradation.
Studies indicate that binding of dynactin (show DCTN1 Proteins), LIS1 (show PAFAH1B1 Proteins) and NudEL regulate cytoplasmic dynein (show DYNC1H1 Proteins) motor activity.
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X.
nudE nuclear distribution gene E homolog (A. nidulans)-like 1
, nuclear disribution gene E like
, nuclear distribution protein nudE-like 1
, protein Nudel
, endooligopeptidase A
, mitosin-associated protein 1
, mitosin-associated protein MITAP1
, nudE nuclear distribution E homolog-like 1
, nudE nuclear distribution gene E homolog-like 1
, nudE nuclear distribution gene E homolog like 1
, endooligopeptidase A protein
, LIS1-interacting protein NUDEL
, LIS1-interacting protein NUDEL; endooligopeptidase A
, nuclear distribution gene E-like homolog 1