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Mouse (Murine) Polyclonal RAB11A Primary Antibody for ELISA, WB - ABIN249623
Gromov, Celis, Hansen, Tommerup, Gromova, Madsen: Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins. in FEBS letters 1998
Cow (Bovine) Polyclonal RAB11A Primary Antibody for IHC, WB - ABIN2789607
Cebrian, Croce, Guerrero, Blanchard, Mayorga: Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells. in EMBO reports 2016
During neural tube formation Rab11-positive recycling endosomes distribute to the medial apical cell junctions in the neural plate. Polarization was under the control of planar cell polarity signalling, and was necessary for neural plate folding.
Rab11 and the associated motor protein Myosin V play essential roles in both endogenous and ectopic apical constriction, and might be involved in Vangl2 trafficking to the cell surface.
Rab11 expression is required throughout the early embryo for proper left-right patterning.
A requirement for Rab11 in multiciliated cells(MCC) development and support a two-step model, in which the initial polarization of MCC precursors is critical for their integration into the superficial cell layer.
Pard3 and Rab11a are necessary for lumen formation in the neural rod.
The established transgenic lines ubiquitously express EGFP fusions of Rab5c (early endosomes), Rab11a (recycling endosomes), and Rab7 (late endosomes) to study localization and dynamics during development.
The results suggest that Rab11 regulates anterograde transport from the TGN to the plasma membrane and strongly implicate SYP122, rather than SYP121.
irregularly coated vesicle formation is observed only in influenza A virus infected cells and requires an active Rab11 GTPase.
Study suggestes that Rab11a serves as an important oncoprotein and a regulator of YAP in human non-small cell lung cancer.
This review will focus on the structure and function of the novel Rab11-FIP3-Rabin8 dual effector complex and its implications for the targeting of sensory receptors to primary cilia, dysfunction of which causes cilia defects underlying human diseases and disorders know as ciliopathies.
Data suggest that membrane tethering mediated by endosomal RAB11A is drastically and selectively stimulated by its cognate Rab effectors, class V myosins (MYO5A and MYO5B), in a GTP-dependent manner. (RAB11A = ras-related GTPase Rab-11A; MYO5 = myosin class V)
these studies are not only the first to identify alpha4 helix of Rab11a as a protein binding domain on the GTPase but also reveal novel mechanistic insights into the intracellular trafficking of the hIP, and potentially of other members of the GPCR superfamily, involving Rab11-dependent mechanisms
transient expression of ATG16L1 not only inhibited autophagosome biogenesis, but also aberrantly targeted RAB11-positive recycling endosomes, resulting in recycling endosome aggregates.
The results from this analysis indicated that Rab11a, Rab11c(Rab25) and Rab14 were expressed in a wide range of cell lines, including the human placental trophoblastic BeWo cell line.
The results suggest that progressive assembly of vRNA segments may be cell type dependent and that vRNA may be transported through the cytoplasm without Rab11A-containing recycling endosomes in the absence of intact microtubules.
Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation
In colorectal carcinoma, overexpression of Rab11 was found to promote collective cell migration through the increased distribution of E-cadherin, which enhanced cell-cell connections.
A novel tribasic Golgi export signal directs cargo protein interaction with activated Rab11 and AP-1-dependent Golgi-plasma membrane trafficking.
Analysis reveals novel aspects of the PI4KIIIb-Rab11 complex, specifically conformational changes induced in the switch regions of activated Rab11.
Substituted V20 of Rab11A was found to interfere with proper localization of the water molecule, which mediated GTP hydrolysis, resulting in GTP being locked in an active form of Rab11A S20V.
Data (including data from studies in knockout mice) suggest Munc13-4 binds to Rab11 and regulates trafficking of Rab11-containing vesicles; Munc13-4 appears to regulate final steps of Rab11-positive vesicle docking at plasma membrane in exocytosis.
Rab11A and Rab11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms
Rab11a/Rab11 family-interacting protein 2-mediated VE-cadherin recycling is required for formation of adherens junctions and restoration of vascular endothelial barrier integrity.
Authors show that Rab11-GMPPNP-FIP3-Rabin8 is more stable than Rab11-GMPPNP-Rabin8, owing to direct interaction between Rabin8 and FIP3 within the dual effector-bound complex.
Mumps Virus release from the apical surface of polarized epithelial cells is facilitated by a Rab11-mediated transport system.
Vaccinia virus traffics to early endosomes, where recycling endosome markers Rab11 and Rab22 are recruited to participate in subsequent virus trafficking prior to virus core uncoating in the cytoplasm.
Rab11a-knockdown cells displayed mislocalization of STX3 and the presentation of microvilli in the basolateral compartment
While RAB11a recruits its effector RAB11FIP3 and cytoskeletal motor Dynein, RAB27b mobilizes the effector MyRIP and motor Myosin VIIa to mediate bacterial expulsion.
Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy.
The authors determined crystal structures of MyoVa-globular tail domain bound either to the Spir-2 motif or to Rab11 and show that a Spir-2:MyoVa:Rab11 complex can form.
Rab11a inactivation in macrophages as a result of apoptotic cell binding initiates phagocytosis of apoptotic neutrophils via the modulation of ADAM17-mediated CD36 cell surface expression
Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors
The up-regulation of Rab11, Rab7, or RILP, but not its truncated form RILP-C33, rescued LAMP2A-defective trafficking in cystinosis, whereas dominant-negative Rab11 or Rab7 impaired LAMP2A trafficking.
Results define Glut3 to be a rab11-dependent trafficking cargo and suggest that impaired Glut3 trafficking arising from rab11 dysfunction underlies the glucose hypometabolism observed in Huntington's disease
LMTK1 negatively controls dendritic formation by regulating Rab11A-positive endosomal trafficking.
Rab11a critically controls mouse blastocyst development and soluble matrix metalloproteinase secretion
Thus, Rab11a endosome controls intestinal host-microbial homeostasis at least partially via sorting Toll-like receptors, including Tlr9.
The unusual morphology and sorting capacity of Rab11a compartments in primary proximal tubule cells may reflect a unique specialization of these cells to accommodate the functional demands of handling a high endocytic load.
These results suggest that deficient activity of Rab11 is a novel mechanism for glucose hypometabolism in Huntington's disease.
Enhanced axonal outgrowth is diminished by inactivation of Rab11A, placing LMTK1 upstream of Rab11A.
A novel mechanism for Huntington's disease involves early deficits in the control of Rab11 activity arising from diminished Rab11 expression at recycling endosomes.
These data demonstrated the important role of Rab11a in the trafficking of TRPV5 and TRPV6.
Study shows that both Rab11 and its effector Rip11 participate in insulin granule exocytosis and that Rip11, as a substrate of PKA, regulates the potentiation of exocytosis by cAMP in pancreatic beta-cells.
Rab11a promotes Porcine reproductive and respiratory syndrome virus (PRRSV) replication and associates with PRRSV replication sites.
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene.
RAB11A, member RAS oncogene family
, ras-related protein Rab-11A
, Rab11 GTPase
, rab11A protein
, Rab11a, GTPase
, rab11A, RAB family GTPase
, RAB 11A, member oncogene family
, rab11 GTP-binding protein
, tubulovesicle-associated protein