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anti-Human ARNT Antibodies:
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Cow (Bovine) Monoclonal ARNT Primary Antibody for ChIP, GS - ABIN151055
Alam, Maizels, Park, Ghaey, Feiger, Chandel, Hunzicker-Dunn et al.: Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is ... in The Journal of biological chemistry 2004
Show all 92 Pubmed References
Cow (Bovine) Polyclonal ARNT Primary Antibody for ChIP, GS - ABIN151037
Sulentic, Holsapple, Kaminski: Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway. in The Journal of pharmacology and experimental therapeutics 2000
Show all 40 Pubmed References
Human Polyclonal ARNT Primary Antibody for WB - ABIN3043528
Wang, Leng, Zhang, Xue, Kang, Zhang: Oxidative stress and hypoxia-induced factor 1α expression in gastric ischemia. in World journal of gastroenterology 2011
Show all 30 Pubmed References
Amphibian Monoclonal ARNT Primary Antibody for GS, ICC - ABIN152684
Singh, Wyman, Casado, Garrett, Gasiewicz: Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells. in Carcinogenesis 2009
Show all 11 Pubmed References
Monoclonal ARNT Primary Antibody for IHC (p), WB - ABIN534093
Do, Fink, Jensen, Gautier, Parlesak: TLR2 controls intestinal carcinogen detoxication by CYP1A1. in PLoS ONE 2012
Show all 6 Pubmed References
Human Polyclonal ARNT Primary Antibody for IF, WB - ABIN513506
Miranda, Nordgren, Male, Lawrence, Hoakwie, Cuda, Court, Fox, Townsend, Packham, Eccles, Tavassoli: A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. in Journal of the American Chemical Society 2013
Cow (Bovine) Polyclonal ARNT Primary Antibody for WB - ABIN2777195
Kurlak, Mistry, Cindrova-Davies, Burton, Broughton Pipkin: Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult. in The Journal of physiology 2016
Human Monoclonal ARNT Primary Antibody for FACS, IF - ABIN2722724
Hao, Bhakti, Peet, Whitelaw: Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation. in Nucleic acids research 2013
Hypoxia-inducible factor (HIF)-1 is a transcription factor comprised of HIF-1a and HIF-1b subunits that play a critical role in alcohol-mediated organ dysfunction. This review provides a comprehensive analysis of recent studies examining the relationship between HIF-1alpha and alcohol consumption as it relates to multiple organ injury and potential therapies to mitigate alcohol's effects.
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF1A and HIF1B binding to a MYC enhancer.
in transcriptionally active heterodimer with AHR, which recognizes the dioxin response element (DRE) in the promoter of downstream genes, right next to the DRE-docking sites is the extensive dimerization surface that is more hydrophobic than other surface areas, indicating that the dimerization interface of the AHR transcription complex is largely dictated by hydrophobic contacts
Here the authors examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets.
Findings reveal that certain blood cancers rely on ARNT isoform 1 to potentiate proliferation by antagonizing RelB and p53-dependent cell cycle arrest and apoptosis.
The structure clearly disclosed that AhRR competitively represses AhR binding to ARNT and target DNA and further suggested the existence of an AhRR-ARNT-specific repression mechanism. This study provides a structural basis for understanding the mechanism by which AhRR represses AhR-mediated gene transcription.
Study showed that polymorphism rs2228099 of the ARNT gene could be a novel susceptibility gene to essential hypertension.
The results revealed a HIF-1alpha-dependent mechanism leading to ARNT upregulation in hypoxia.
The protein levels of phosphorylated (p)Akt, Erk1/2, pErk1/2, HIF1alpha and HIF1beta were significantly increased by 5.89, 0.5, 0.59, 1.46 and 0.92fold, respectively, in the patients with PAH, compared with those in the controls group
Report quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator.
this study shows that ARNT is upregulated in skin from atopic dermatitis patients in China
Data suggest that activation of the AhR/ARNT (aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator) signaling by AhR ligands (environmental carcinogens TCDD/3MC/PCB used here) represents novel mechanism for regulating the expression of ADH1B (alcohol dehydrogenase 1B) and other isoenzymes (ADH4, ADH6) in hepatocytes.
Authors report here that not only HIF1alpha but also ARNT regulates VEGF expression in 3D cancer spheroids. Results suggest the utility of the in vitro 3D cancer spheroid model for investigating angiogenesis in cancerous tissues.
The results of this study indicate that ARNT depletion renders tumour cells susceptible to radiation whereas overexpression of this transcription factor confers radioresistance
HIF-1beta might act as a novel cross-link between the HIF and NF-kappaB pathways in suppression of angiogenesis by LDL, while proteasome inhibitors might promote angiogenesis by reactivating this signaling cascade under hyperlipidemia.
ARNT Val189Val polymorphism is not associated with endometriosis in Asians.
HIF1 regulates claudin-1 in intestinal epithelium. This regulation is important for intestinal epithelial tight junction integrity.
Down-regulation of ARNT promotes colorectal cancer metastasis by activating the fibronectin/integrin beta1/FAK axis.
AhR/ARNT activation and overexpression of BCL6 are collectively responsible for differential expression of more than 100 genes in diffuse large B-cell lymphoma cell line.
Data indicate that silencing of hypoxia-inducible factor-1 beta (HIF-1beta) sensitizes tumor cells to hypoxic apoptosis.
Results elucidate the dimerization process of AhR with ARNT and propose the structure of the N-terminal region of the AhR:ARNT dimer including the bHLH, PAS-A and PAS-B domains.
results provide convincing evidence that reduced hepatic ARNT can contribute to inappropriate hepatic glucose production and post-prandial dyslipidaemia
These promoters possess potential signature sequences for common as well as different transcription factors suggesting complex regulation of Arnt gene.
The only in vivo defects found in beta-Arnt mice were significant increases in the respiratory exchange ratio and in vivo carbohydrate oxidation, and a decrease in lipid oxidation
hepatocyte ARNT is not a requirement for initiation of liver fibrogenesis, but does regulate pro-fibrotic gene expression and macrophage accumulation.
HIF-1beta hepatocyte-specific knockout mice had less liver injury and steatosis in response to Gao-binge ethanol treatment.
Candidate gene analysis focused on Arnt as an influence on circadian regulation in the 'drinking in the dark' phenotype of alcohol consumption.
crystal structures for each of mouse HIF-2alpha-ARNT and HIF-1alpha-ARNT heterodimers in states that include bound small molecules and their hypoxia response element
We determined that ARNT is essential for adult and fetal hematopoietic stem cell viability and homeostasis.
ARNT is a critical regulator of myocardial fatty acid metabolism and its deletion leads to cardiomyopathy and an increase in triglyceride accumulation through PPARA.
This study demonstrates for the first time the requirement of HIF1 for FSH-regulated Vegfa expression in vivo and that HIF1 acts via a single hypoxia response element in the Vegfa promoter to exert its regulatory functions.
Outcomes for islet transplants lacking beta-cell ARNT were poor.
HIF-1a and its dimerization partner HIF-1b/Arnt occupy the first intron region of the mouse JMJD3 gene.
Myeloid ARNT is important for innate immune function and wound healing.
results suggest that the HIF-2alpha/ARNT complex regulates hair follicle differentiation via induction of p21(Waf1/Cip1) and possibly p27(Kip1)
Islet ARNT increases in normal murine pregnancy and beta-cell ARNT is required for cyclinD2 induction and increased beta-cell proliferation in pregnancy.
The ARNT-STAT3 axis is a critical regulator of TCRalphabeta CD8alphaalpha intestinal intraepithelial T-cell development and differentiation.
show that exposure of C2C12 myocytes to cyclic hypoxia and reoxygenation rapidly increased levels of IL-10 mRNA, which was blocked by administration of the HIF-1 inhibitor acriflavine or by expression of short hairpin RNA targeting HIF-1alpha or HIF-1beta.
Expressions of Dbp and Arnt were dampened in the islets of a diabetic model mouse.
Deficiency of HIF-1alpha or HIF-1beta in Tie2-lineage cells resulted in delayed wound closure, reduced vascularization, decreased cutaneous blood flow, impaired bone marrow-derived angiogenic cell (BMDAC) mobilization, and decreased BMDAC homing to burn wounds.
zfARNT1 proteins are required for ptotection against 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity.
Morpholino experiments show that knockdown of ARNT1 offers protection from TCCD-induced cardiotoxicity.
The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1\;12)(q21\;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.
class E basic helix-loop-helix protein 2
, dioxin receptor, nuclear translocator
, hypoxia-inducible factor 1, beta subunit
, ARNT protein
, HIF-1 beta
, aryl hydrocarbon receptor nuclear translocator
, hypoxia-inducible factor 1 beta
, hypoxia-inducible factor 1-beta
, Aryl hydrocarbon receptor nuclear translocator 1
, aryl hydrocarbon receptor nuclear translocater
, aryl hydrocarbon receptor nuclear translocator 2