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anti-Human ARNT Antibodies:
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Cow (Bovine) Monoclonal ARNT Primary Antibody for ChIP, GS - ABIN151055
Alam, Maizels, Park, Ghaey, Feiger, Chandel, Hunzicker-Dunn et al.: Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is ... in The Journal of biological chemistry 2004
Show all 91 Pubmed References
Cow (Bovine) Polyclonal ARNT Primary Antibody for ChIP, GS - ABIN151037
Sulentic, Holsapple, Kaminski: Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway. in The Journal of pharmacology and experimental therapeutics 2000
Show all 38 Pubmed References
Human Polyclonal ARNT Primary Antibody for WB - ABIN3043528
Wang, Leng, Zhang, Xue, Kang, Zhang: Oxidative stress and hypoxia-induced factor 1α expression in gastric ischemia. in World journal of gastroenterology 2011
Show all 30 Pubmed References
Amphibian Monoclonal ARNT Primary Antibody for GS, ICC - ABIN152684
Singh, Wyman, Casado, Garrett, Gasiewicz: Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells. in Carcinogenesis 2009
Show all 11 Pubmed References
Human Polyclonal ARNT Primary Antibody for IF, WB - ABIN513506
Miranda, Nordgren, Male, Lawrence, Hoakwie, Cuda, Court, Fox, Townsend, Packham, Eccles, Tavassoli: A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. in Journal of the American Chemical Society 2013
Cow (Bovine) Polyclonal ARNT Primary Antibody for WB - ABIN2777195
Kurlak, Mistry, Cindrova-Davies, Burton, Broughton Pipkin: Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult. in The Journal of physiology 2016
Human Monoclonal ARNT Primary Antibody for FACS, IF - ABIN2722724
Hao, Bhakti, Peet, Whitelaw: Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation. in Nucleic acids research 2013
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF1A (show HIF1A Antibodies) and HIF1B binding to a MYC (show MYC Antibodies) enhancer.
in transcriptionally active heterodimer with AHR (show AHR Antibodies), which recognizes the dioxin response element (DRE (show SUFUH Antibodies)) in the promoter of downstream genes, right next to the DRE (show SUFUH Antibodies)-docking sites is the extensive dimerization surface that is more hydrophobic than other surface areas, indicating that the dimerization interface of the AHR (show AHR Antibodies) transcription complex is largely dictated by hydrophobic contacts
Here the authors examined the crystal structures of multi-domain NPAS1 (show NPAS1 Antibodies)-ARNT and NPAS3 (show NPAS3 Antibodies)-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets.
Findings reveal that certain blood cancers rely on ARNT isoform 1 to potentiate proliferation by antagonizing RelB (show RELB Antibodies) and p53 (show TP53 Antibodies)-dependent cell cycle arrest and apoptosis.
The structure clearly disclosed that AhRR (show CYP1A1 Antibodies) competitively represses AhR (show AHR Antibodies) binding to ARNT and target DNA and further suggested the existence of an AhRR (show CYP1A1 Antibodies)-ARNT-specific repression mechanism. This study provides a structural basis for understanding the mechanism by which AhRR (show CYP1A1 Antibodies) represses AhR (show AHR Antibodies)-mediated gene transcription.
Study showed that polymorphism rs2228099 of the ARNT gene could be a novel susceptibility gene to essential hypertension.
The results revealed a HIF-1alpha (show HIF1A Antibodies)-dependent mechanism leading to ARNT upregulation in hypoxia.
The protein levels of phosphorylated (p)Akt, Erk1/2, pErk1/2, HIF1alpha and HIF1beta were significantly increased by 5.89, 0.5, 0.59, 1.46 and 0.92fold, respectively, in the patients with PAH, compared with those in the controls group
Report quinone-mediated induction of cytochrome P450 1A1 (show CYP1A1 Antibodies) in HepG2 cells through increased interaction of aryl hydrocarbon receptor (show AHR Antibodies) with aryl hydrocarbon receptor nuclear translocator.
this study shows that ARNT is upregulated in skin from atopic dermatitis patients in China
Results elucidate the dimerization process of AhR (show AHR Antibodies) with ARNT and propose the structure of the N-terminal region of the AhR:ARNT dimer including the bHLH, PAS (show PASK Antibodies)-A and PAS (show PASK Antibodies)-B domains.
results provide convincing evidence that reduced hepatic ARNT can contribute to inappropriate hepatic glucose production and post-prandial dyslipidaemia
These promoters possess potential signature sequences for common as well as different transcription factors suggesting complex regulation of Arnt gene.
The only in vivo defects found in beta-Arnt mice were significant increases in the respiratory exchange ratio and in vivo carbohydrate oxidation, and a decrease in lipid oxidation
hepatocyte ARNT is not a requirement for initiation of liver fibrogenesis, but does regulate pro-fibrotic gene expression and macrophage accumulation.
HIF-1beta hepatocyte-specific knockout mice had less liver injury and steatosis in response to Gao-binge ethanol treatment.
Candidate gene analysis focused on Arnt as an influence on circadian regulation in the 'drinking in the dark' phenotype of alcohol consumption.
crystal structures for each of mouse HIF-2alpha (show EPAS1 Antibodies)-ARNT and HIF-1alpha (show HIF1A Antibodies)-ARNT heterodimers in states that include bound small molecules and their hypoxia response element
We determined that ARNT is essential for adult and fetal hematopoietic stem cell viability and homeostasis.
ARNT is a critical regulator of myocardial fatty acid metabolism and its deletion leads to cardiomyopathy and an increase in triglyceride accumulation through PPARA (show PPARA Antibodies).
Morpholino experiments show that knockdown of ARNT1 offers protection from TCCD-induced cardiotoxicity.
The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1\;12)(q21\;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.
class E basic helix-loop-helix protein 2
, dioxin receptor, nuclear translocator
, hypoxia-inducible factor 1, beta subunit
, ARNT protein
, HIF-1 beta
, aryl hydrocarbon receptor nuclear translocator
, hypoxia-inducible factor 1 beta
, hypoxia-inducible factor 1-beta
, Aryl hydrocarbon receptor nuclear translocator 1
, aryl hydrocarbon receptor nuclear translocater
, aryl hydrocarbon receptor nuclear translocator 2