anti-Rat (Rattus) Lysine (K)-Specific Demethylase 1A antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended Lysine (K)-Specific Demethylase 1A Antibody (supplied by: Log in to see )

Antigen
Lysine (K)-Specific Demethylase 1A (KDM1A) Antibodies
  • AOF2
  • BHC110
  • KDM1
  • LSD1
  • 1810043O07Rik
  • AA408884
  • Aof2
  • D4Ertd478e
  • Kdm1
  • Lsd1
  • mKIAA0601
  • DKFZp459N2450
  • RGD1562975
  • aof2
  • kdm1
  • wu:fb82e06
  • wu:fc51a02
  • wu:fj36a05
  • wu:fj66b06
  • KDM1A
  • lsd1
  • xLSD1
  • lysine demethylase 1A
  • lysine (K)-specific demethylase 1A
  • lysine (K)-specific demethylase 1a
  • KDM1A
  • Kdm1a
  • kdm1a
Reactivity
Human, Mouse (Murine), Rat (Rattus)
202
119
94
23
21
10
9
6
6
4
3
3
1
1
1
Host
Rabbit
152
49
4
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
173
72
61
48
31
25
17
14
9
8
6
6
3
3
1
1
1
Options
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Catalog No. ABIN704606
$ 306.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2803555 IF (p) Alexa Fluor 594 Rabbit IgG AA 120-170 Log in to see Polyclonal 0
1 ABIN704613 IF (p) FITC Rabbit IgG Log in to see Polyclonal 0
1 ABIN903560 IF (p) Alexa Fluor 555 Rabbit IgG Log in to see Polyclonal 0
1 ABIN903562 IF (p) Alexa Fluor 647 Rabbit IgG Log in to see Polyclonal 0
1 ABIN903558 IF (p) Alexa Fluor 350 Rabbit IgG Log in to see Polyclonal 0
1 ABIN704612 IF (p) Cy7 Rabbit IgG Log in to see Polyclonal 0
1 ABIN704611 IF (p) Cy5.5 Rabbit IgG Log in to see Polyclonal 0
1 ABIN704610 IF (p) Cy5 Rabbit IgG Log in to see Polyclonal 0
1 ABIN704609 IF (p) Cy3 Rabbit IgG Log in to see Polyclonal 0
1 ABIN903561 IF (p) Alexa Fluor 488 Rabbit IgG Log in to see Polyclonal 0
1 ABIN5005830 IF (p) Alexa Fluor 750 Rabbit IgG AA 120-170 Log in to see Polyclonal 0
1 ABIN5005829 IF (p) Alexa Fluor 680 Rabbit IgG AA 120-170 Log in to see Polyclonal 0
1 ABIN1706288 IF (p) Cy5.5 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1709910 IF (p) FITC Rabbit IgG Log in to see Polyclonal 0
1 ABIN1697082 IF (p) Alexa Fluor 555 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1702519 IF (p) Cy3 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1704330 IF (p) Cy5 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1708099 IF (p) Cy7 Rabbit IgG Log in to see Polyclonal 0
1 ABIN2803554 IF (p) Alexa Fluor 594 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1693439 IF (p) Alexa Fluor 350 Rabbit IgG Log in to see Polyclonal 0

General

Antigen Lysine (K)-Specific Demethylase 1A (KDM1A) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(202), (119), (94), (23), (21), (10), (9), (6), (6), (4), (3), (3), (1), (1), (1)
Host Rabbit
(152), (49), (4)
Clonality
Polyclonal
Conjugate Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(173), (72), (61), (48), (31), (25), (17), (14), (9), (8), (6), (6), (3), (3), (1), (1), (1)
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Product details

Target Details Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human KDM1A
Isotype IgG

Target Details

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Antigen
Alternative Name Kdm1 (KDM1A Antibody Abstract)
Background

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.

Subcellular location: Nucleus

Synonyms: AOF2, KDM1, LSD1, BHC110, Lysine-specific histone demethylase 1A, BRAF35-HDAC complex protein BHC110, Flavin-containing amine oxidase domain-containing protein 2, KDM1A, KIAA0601

Gene ID 23028
UniProt O60341
Pathways Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling

Application Details

Product details Target Details Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

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Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

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Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody (ABIN704606) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-KDM1 Polyclon...