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anti-Human POR Antibodies:
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Arabidopsis thaliana Polyclonal POR Primary Antibody for WB - ABIN2688654
Wei, Zhou, Hu, Wei, Yang, Huang: Heterotrimeric G-protein is involved in phytochrome A-mediated cell death of Arabidopsis hypocotyls. in Cell research 2008
Show all 6 Pubmed References
Arabidopsis thaliana Polyclonal POR Primary Antibody for WB - ABIN349645
Wei, Zhou, Hu, Wei, Yang, Huang: Heterotrimeric G-protein is involved in phytochrome A-mediated cell death of Arabidopsis hypocotyls. in Cell research 2009
Show all 5 Pubmed References
Cow (Bovine) Polyclonal POR Primary Antibody for IHC, WB - ABIN2773843
Lee, Kim, Yoon, Lee: Cytochrome P450 system expression and DNA adduct formation in the liver of Zacco platypus following waterborne benzo(a)pyrene exposure: implications for biomarker determination. in Environmental toxicology 2014
Human Polyclonal POR Primary Antibody for IF, WB - ABIN950123
Araki, Tsuruoka, Hasegawa, Yanagihara, Omasa, Enosawa, Yamazoe, Fujimura: Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells. in The Journal of pharmacy and pharmacology 2012
CYP3A5, ABCB1 and two POR genotypes were assessed by real-time PCR.
Both CYP1A2 and CYP2B4 activities were affected by their coexpression in a manner consistent with formation of the high-affinity POR-CYP1A2-CYP2B4 complex.
genetic association studies in population in Scotland: data suggest, in type 2 diabetes treated with sulfonylureas, 2 SNPs in CYP2C9 (CYP2C9*2, R144C, rs1799853; CYP2C9*3, I359L, rs1057910) are associated with drug-induced hypoglycemia; an SNP in POR (POR*28, A503V, rs1057868) is associated with better response to sulfonylureas. (CYP2C9 = cytochrome P450 family 2 subfamily C member 9; POR = cytochrome p450 oxidoreductase)
The POR*28 heterozygote appears to be associated with the stable dose of acenocoumarol.
Younger age, POR*28 allele, and CYP3A5*3 allele were associated with higher cyclosporine dosing requirements and lower concentration/dose ratio.
Suggest that hepatic POR and P450s are coregulated, and that POR plays a complex role in P450-mediated metabolism.
A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17. (Review)
Compound heterozygosity of a paternal submicroscopic deletion and a maternal missense mutation in POR gene: Antley-bixler syndrome phenotype in three sibling fetuses
To promote intracellular iron flux, an iron chaperone appears to be essential for receiving iron from heme catabolism. Data suggest that PCBP2 competes with CPR for binding HO1; PCBP2 K homology 3 domain is important for HO1/PCBP2 interaction; heme prompts HO1/CPR multimer and decreases HO1/PCBP2 multimer. [PCBP2 = poly(rC) binding protein 2; CPR = cytochrome P450 reductase; HO1 = heme oxidase 1]
analysis of mutations and polymorphisms in POR linked to metabolism of steroids and xenobiotics and pathology of P450 oxidoreductase deficiency (PORD)
No significant differences in the distribution of haplotypes between cases and controls were detected. In conclusion, this study reveals that four SNPs in the POR gene (rs3823884, rs3898649, rs239953 and rs17685) may affect the susceptibility of smoking cessation in a Chinese Han population.
analysis of the role of the active site loop in coenzyme binding and flavin reduction in cytochrome P450 reductase
Current studies demonstrate that, unlike previously described mutations, A287P causes POR deficiency disorder due to conformational instability leading to proteolytic susceptibility in vivo, rather than through an inherent flavin-binding defect.
population pharmacokinetic analysis identified that the combined genotype of CYP3A5-POR was the only covariant for the apparent clearance of tacrolimus
Case Report: delayed diagnosis of 46, XY disorder of sex development due to P450 oxidoreductase (POR) deficiency.
Interindividual variability in CYP2C19 activity is due to differences in both CYP2C19 protein content associated with gene diplotypes and the cytochrome P450 oxidoreductase content.
POR rs2868177 and CYP2B6*6 variants contribute to the interindividual variability in human CYP2B6 activity, which may affect the disposition and interaction of other CYP2B6 substrate drugs
For the first time, the SNP POR*37 831-35C>T was confirmed as a minor but statistically significant factor associated with inter-individual variation in warfarin maintenance dose in Han Chinese
POR*28 does not significantly influence Tac pharmacokinetic parameters.
the POR g.6593A>G polymorphism significantly influences CYP2B6 activity
Data indicate not only that binding of b5 and P450 reductase on the proximal surface of P450 2B4 results in electron transfer but also that each redox partner transmits unique structural information to the active site proton delivery network.
Results show that equine CYP3A94 is metabolically active and its activity is dependent on an adequate level of POR.
It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase and cytochrome b(5).
NADPH-P450 reductase (NPR) was purified from hepatic microsomes of Xenopus laevis.
Knockout of the cytochrome P450 reductase by CRISPR/Cas9 technology (POR(-/-)) in HEK293 cells overexpressing Nox4 or Nox5 did not interfere with ROS production in intact cells. However, POR(-/-) abolished the signal in NADPH-stimulated assays using membrane fractions from the very same cells. Moreover, membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH-dependent signal with lucigen
we observed that miR-378 modulates the oscillation amplitudes of Cdkn1a in the control of cell cycle and Por in the regulation of oxidation reduction by forming partnership with different circadian transcription factors
Results are the first to show that some forms of opioid-mediated stress-induced analgesia require brain neuronal P450 activity.
Immunological and metabolic changes resulting from a genetic deficiency in CPR expression in the intestine in mice.
An apparent link exists between the cytochrome p450 reductase and FGF signaling pathways.
These data collectively indicate a novel role of the Cpr gene in fear conditioning and memory.
this study provides novel insights into the regulation of gap junction function by CYPOR and suggests that Cx43 may play an important role(s) in CYPOR-mediated bone defects seen in patients.
inactivation of the hepatic cytochrome P450 system by conditional deletion of this enzyme
Changes in hepatic mRNA expression using microarray analysis and real-time PCR in POR null mice are reported.
POR function is indispensable for the proper regulation of retinoic acid levels and tissue distribution not only during early embryonic development but also in later morphogenesis and molecular patterning of the brain, abdominal/caudal region and limbs.
The hepatic deficiency of this enzyme reverberates throughout the biological system and produces a coordinated response to the low levels of circulating cholesterol and bile.
Data suggest that cellular cytochrome P450 oxidoreductase-dependent cholesterol synthesis is essential during limb and skeletal development.
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
NADPH--cytochrome P450 reductase
, NADPH-dependent cytochrome P450 reductase
, cytochrome P450 reductase
, P450 (cytochrome) oxidoreductase
, NADPH-cytochrome P450 reductase
, NADPH-cytochrome P-450 oxidoreductase
, NADPH-cytochrome P450 oxidoreductase
, P450 reductase
, cytochrome c reductase (NADPH)
, NADPH-P450 reductase
, NADPH--cytochrome P450 reductase-like
, NADH cytochrome P450 oxydoreductase