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anti-Human POR Antibodies:
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Arabidopsis thaliana Polyclonal POR Primary Antibody for WB - ABIN349645
Wei, Zhou, Hu, Wei, Yang, Huang: Heterotrimeric G-protein is involved in phytochrome A-mediated cell death of Arabidopsis hypocotyls. in Cell research 2009
Show all 5 Pubmed References
Arabidopsis thaliana Polyclonal POR Primary Antibody for WB - ABIN2688654
Wei, Zhou, Hu, Wei, Yang, Huang: Heterotrimeric G-protein is involved in phytochrome A-mediated cell death of Arabidopsis hypocotyls. in Cell research 2008
Show all 6 Pubmed References
Human Polyclonal POR Primary Antibody for IF, WB - ABIN950123
Araki, Tsuruoka, Hasegawa, Yanagihara, Omasa, Enosawa, Yamazoe, Fujimura: Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells. in The Journal of pharmacy and pharmacology 2012
Cow (Bovine) Polyclonal POR Primary Antibody for IHC, WB - ABIN2773843
Lee, Kim, Yoon, Lee: Cytochrome P450 system expression and DNA adduct formation in the liver of Zacco platypus following waterborne benzo(a)pyrene exposure: implications for biomarker determination. in Environmental toxicology 2014
Both CYP1A2 (show CYP1A2 Antibodies) and CYP2B4 activities were affected by their coexpression in a manner consistent with formation of the high-affinity POR-CYP1A2 (show CYP1A2 Antibodies)-CYP2B4 complex.
genetic association studies in population in Scotland: data suggest, in type 2 diabetes treated with sulfonylureas, 2 SNPs in CYP2C9 (CYP2C9 (show CYP2C9 Antibodies)*2, R144C, rs1799853; CYP2C9 (show CYP2C9 Antibodies)*3, I359L, rs1057910) are associated with drug-induced hypoglycemia; an SNP in POR (POR*28, A503V, rs1057868) is associated with better response to sulfonylureas. (CYP2C9 (show CYP2C9 Antibodies) = cytochrome P450 (show CYP Antibodies) family 2 subfamily C (show CYP Antibodies) member 9; POR = cytochrome p450 (show CYP Antibodies) oxidoreductase (show TXNRD1 Antibodies))
The POR*28 heterozygote appears to be associated with the stable dose of acenocoumarol.
Younger age, POR*28 allele, and CYP3A5 (show CYP3A5 Antibodies)*3 allele were associated with higher cyclosporine dosing requirements and lower concentration/dose ratio.
Suggest that hepatic POR and P450s are coregulated, and that POR plays a complex role in P450 (show CYP2B6 Antibodies)-mediated metabolism.
A homodimer model can resolve the conundrum as to how cytochrome P450 (show CYP Antibodies) oxidoreductase (show TXNRD1 Antibodies) and cytochrome b5 (show CYB5A Antibodies) compete for the same binding site on cytochrome P450c17 (show CYP17A1 Antibodies). (Review)
Compound heterozygosity of a paternal submicroscopic deletion and a maternal missense mutation in POR gene: Antley-bixler syndrome phenotype in three sibling fetuses
To promote intracellular iron flux, an iron chaperone appears to be essential for receiving iron from heme catabolism. Data suggest that PCBP2 (show PCBP2 Antibodies) competes with CPR for binding HO1 (show HMOX1 Antibodies); PCBP2 (show PCBP2 Antibodies) K homology 3 domain is important for HO1 (show HMOX1 Antibodies)/PCBP2 (show PCBP2 Antibodies) interaction; heme prompts HO1 (show HMOX1 Antibodies)/CPR multimer and decreases HO1 (show HMOX1 Antibodies)/PCBP2 (show PCBP2 Antibodies) multimer. [PCBP2 (show PCBP2 Antibodies) = poly(rC) binding protein 2 (show PCBP2 Antibodies); CPR = cytochrome P450 reductase; HO1 (show HMOX1 Antibodies) = heme oxidase 1]
analysis of mutations and polymorphisms in POR linked to metabolism of steroids and xenobiotics and pathology of P450 (show CYP2B6 Antibodies) oxidoreductase (show TXNRD1 Antibodies) deficiency (PORD)
No significant differences in the distribution of haplotypes between cases and controls were detected. In conclusion, this study reveals that four SNPs in the POR gene (rs3823884, rs3898649, rs239953 and rs17685) may affect the susceptibility of smoking cessation in a Chinese Han population.
Data indicate not only that binding of b5 and P450 reductase on the proximal surface of P450 2B4 (show CD244 Antibodies) results in electron transfer but also that each redox partner transmits unique structural information to the active site proton delivery network.
Results show that equine CYP3A94 is metabolically active and its activity is dependent on an adequate level of POR (show CYP2B4 Antibodies).
It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase and cytochrome b(5 (show CYB5A Antibodies)).
NADPH-P450 reductase (NPR) was purified from hepatic microsomes of Xenopus laevis.
Knockout of the cytochrome P450 reductase by CRISPR/Cas9 technology (POR(-/-)) in HEK293 cells overexpressing Nox4 or Nox5 did not interfere with ROS production in intact cells. However, POR(-/-) abolished the signal in NADPH-stimulated assays using membrane fractions from the very same cells. Moreover, membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH-dependent signal with lucigen
we observed that miR (show MLXIP Antibodies)-378 modulates the oscillation amplitudes of Cdkn1a (show CDKN1A Antibodies) in the control of cell cycle and Por in the regulation of oxidation reduction by forming partnership with different circadian transcription factors
Results are the first to show that some forms of opioid-mediated stress-induced analgesia require brain neuronal P450 activity.
Immunological and metabolic changes resulting from a genetic deficiency in CPR (show GRID2 Antibodies) expression in the intestine in mice.
An apparent link exists between the cytochrome p450 reductase and FGF signaling pathways.
These data collectively indicate a novel role of the Cpr (show GRID2 Antibodies) gene in fear conditioning and memory.
this study provides novel insights into the regulation of gap junction function by CYPOR and suggests that Cx43 (show GJA1 Antibodies) may play an important role(s) in CYPOR-mediated bone defects seen in patients.
inactivation of the hepatic cytochrome P450 (show CYP Antibodies) system by conditional deletion of this enzyme
Changes in hepatic mRNA expression using microarray analysis and real-time PCR in POR null mice are reported.
POR function is indispensable for the proper regulation of retinoic acid levels and tissue distribution not only during early embryonic development but also in later morphogenesis and molecular patterning of the brain, abdominal/caudal (show CAD Antibodies) region and limbs.
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
NADPH--cytochrome P450 reductase
, NADPH-dependent cytochrome P450 reductase
, cytochrome P450 reductase
, P450 (cytochrome) oxidoreductase
, NADPH-cytochrome P450 reductase
, NADPH-cytochrome P-450 oxidoreductase
, NADPH-cytochrome P450 oxidoreductase
, P450 reductase
, cytochrome c reductase (NADPH)
, NADPH-P450 reductase
, NADPH--cytochrome P450 reductase-like
, NADH cytochrome P450 oxydoreductase