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PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes.
Results suggest that modulation of the expression of receptors and CD112 compensates for CD155 (show PVR Proteins) deficiency in immune surveillance against methylcholanthrene-induced tumors.
We showed that cadherin and nectin (show PVRL1 Proteins) in the junctions of A431 cells and human keratinocytes are located in separate clusters.
nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis
Our functional analyses indicate that the infertility phenotype of nectin-2-deficient male mice is caused by a combination of reduced migration to the oviduct, spermatozoa-zona binding, and sperm-oocyte fusion
nectins and afadin are involved in dynamic epithelial remodeling during mouse development
Nectin-2 expression in Sertoli cells is believed via cross-talking between CREB (show CREB1 Proteins), c-Jun (show JUN Proteins), and Sp1 (show SP1 Proteins) family protein.
Inactivated nectin-2 and nectin-3 disrupted the nectin-afadin-actin system, and finally the actin filaments disappeared. As a result, the specialization lost the holding function and detachment of spermatids was observed.
Nectin-2 is required to maintain structure and function of the intercalated disc and protects the heart from pressure-overload-induced cardiac dysfunction.
Nectin-2 mutation in men with severe teratospermia
In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin (show PVRL1 Proteins)-2Ig.
Our data provide important structural and biochemical determinants responsible for the recognition of nectin-2 by TIGIT (show TIGIT Proteins).
Chromosomal breakpoints involved the PVRR2 gene in 19q31 is associated with Diffuse Large B-Cell Lymphomas.
energetic basis for the TIGIT (show TIGIT Proteins)/nectin-2 interaction and revealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the lock were tolerated.
Serum levels of nectin-2 may have diagnostic roles for colorectal cancer patients.
Soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection.
PVRL2, TOMM40 (show TOMM40 Proteins) and APOE (show APOE Proteins) might be associated with human longevity.
Nectin-3 (show PVRL3 Proteins) trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation.
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
poliovirus receptor-related protein 2
, herpes virus entry mediator B
, herpesvirus entry mediator B
, murine herpes virus entry protein B
, murine herpesvirus entry protein B
, poliovirus receptor homolog
, poliovirus sensitivity
, poliovirus receptor related 2
, poliovirus receptor-related 2 (herpesvirus entry mediator B)
, herpesvirus entry protein B
, poliovirus receptor-like 2