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these findings uncover a direct cross-talk mechanism between ME1 and PPP, may reveal an alternative model for signaling transduction via protein conformational simulation, and pave the way for better understanding how metabolic pathways are coordinated in cancer.
ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions.
ME1 expression was found to be mutant-KRAS-associated in NSCLC cancer cell lines. Patients with elevated ME1 had worse outcomes after radiotherapy. Transamination generating cytosolic NADPH via ME1 may contribute to radioresistance.
ME1 overexpression associates with unfavorable prognoses in patients with HCC (show FAM126A Proteins), suggesting that ME1 is a poor prognostic predictor of hepatocellular carcinoma.
essential role for ME1 in the production of cytosolic NADPH and maintenance of migratory and invasive abilities of nasopharyngeal carcinoma cells
the differential protein stability between dimer and tetramer interface interactions of human c-NADP-ME
p53 (show TP53 Proteins) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells
cytosolic malic enzyme 1 gene polymorphism is associated with the degree of suppression of parathyroid hormone (show PTH Proteins) after long-term calcium supplementation; the effect is probably mediated through an increase in intestinal calcium absorption
ME1 is a functional target gene of the BACH1 (show BACH1 Proteins) transcription factor according to ChIP-seq and knockdown analysis in HEK (show EPHA3 Proteins) 293 cells.
that the single mutation of Gln362 to Lys in human m-NAD-ME changes it to an NADP+-dependent enzyme, which is characteristic because it is non-allosteric, non-cooperative, and NADP+-specific
This lack of consistency across families, combined with the fact that the ME1 mutation is synonymous and that the two DECR1 (show DECR1 Proteins) polymorphisms are conservative, suggests that the associations found are not causative.
Transcript level of the porcine ME1 gene is affected by SNP in its 3'UTR, which is also associated with subcutaneous fat thickness.
Malic enzyme 1 genotype is associated with backfat thickness and meat quality traits in pigs.
Six novel SNPs, five in ME1 and one in NR0B2 (show NR0B2 Proteins), were identified as candidates that have effects on meat and carcass quality traits.
ME1-Dra I genotypes had a significant effect on cooking loss.
Tcf12 (show TCF12 Proteins) is a transcription factor highly expressed in the nuclei of stem cells and its downregulation plays an essential role in osteoblast differentiation.
Data suggest that Ad4BP (show NR5A1 Proteins) plays role in regulation of intracellular NADPH (show FDXR Proteins) concentration via transcription of Me1 and Mthfd2 (show MTHFD2 Proteins) genes in adrenocortical cells. (Ad4BP (show NR5A1 Proteins) = nuclear receptor subfamily 5 group A member 1 (show NR5A1 Proteins); Me1 = malic enzyme 1; Mthfd2 (show MTHFD2 Proteins) = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
we identified transcription factor TCF12 (show TCF12 Proteins) as a new target of miR (show MLXIP Proteins)-211 in oral squamous cell carcinoma
This study showed that (2)H-labeled tracers enable dissection of NADPH production routes across cell types and environmental conditions.
ME1 expression was found to be mutant-KRAS-associated in an NSCLC mouse model.
HEB is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells
severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 (show TCF12 Proteins) and Twist1 (show TWIST1 Proteins) genes highlights the key role of TCF12 (show TCF12 Proteins) acting with TWIST1 (show TWIST1 Proteins) in the normal development of the coronal sutures
p53 (show TP53 Proteins) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 (show TCF4 Proteins) in human and mouse cells
Deficiency in the E proteins, E2A (show TCF3 Proteins) and HEB, led to increased frequency of terminally differentiated effector KLRG1 (show KLRG1 Proteins)(hi) CD8 (show CD8A Proteins)(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.
Deletion of HEB and E2A (show TCF3 Proteins) in DP thymocytes specifically blocked the development of CD4 (show CD4 Proteins)(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 (show ID3 Proteins) allowed CD4 (show CD4 Proteins)(+) T cell development but blocked CD8 (show CD8A Proteins)(+) lineage development.
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
NADP-dependent malic enzyme
, cytosolic malic enzyme 1
, malic enzyme 1, NADP(+)-dependent, cytosolic
, cytosolic malic enzyme 1-like
, NADP-dependent malic enzyme-like
, Malic enzyme, cytoplasmic
, malate dehydrogenase
, malic enzyme 1, soluble
, pyruvic-malic carboxylase
, malate dehydrogenase decarboxylase (NADP+)
, malic enzyme 1, NADP(+)-dependent, cytoplasmic (cytosolic, soluble)
, malic enzyme, supernatant
, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
, DNA-binding protein HTF4
, E-box-binding protein
, class A helix-loop-helix transcription factor ME1
, transcription factor HTF-4