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Findings indicate that malic enzyme 1 (ME1) is a valid target for molecular therapy in oral squamous cell carcinomas (OSCCs).
The critical roles of miR-30a and ME1 in the development of KRAS-mutant colorectal cancer indicate therapy potentials for this subtype of cancer.
these findings uncover a direct cross-talk mechanism between ME1 and PPP, may reveal an alternative model for signaling transduction via protein conformational simulation, and pave the way for better understanding how metabolic pathways are coordinated in cancer.
ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions.
ME1 expression was found to be mutant-KRAS-associated in NSCLC cancer cell lines. Patients with elevated ME1 had worse outcomes after radiotherapy. Transamination generating cytosolic NADPH via ME1 may contribute to radioresistance.
ME1 overexpression associates with unfavorable prognoses in patients with HCC (show FAM126A Proteins), suggesting that ME1 is a poor prognostic predictor of hepatocellular carcinoma.
essential role for ME1 in the production of cytosolic NADPH and maintenance of migratory and invasive abilities of nasopharyngeal carcinoma cells
the differential protein stability between dimer and tetramer interface interactions of human c-NADP-ME
p53 (show TP53 Proteins) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells
cytosolic malic enzyme 1 gene polymorphism is associated with the degree of suppression of parathyroid hormone (show PTH Proteins) after long-term calcium supplementation; the effect is probably mediated through an increase in intestinal calcium absorption
Data suggest that Ad4BP (show NR5A1 Proteins) plays role in regulation of intracellular NADPH (show FDXR Proteins) concentration via transcription of Me1 and Mthfd2 (show MTHFD2 Proteins) genes in adrenocortical cells. (Ad4BP (show NR5A1 Proteins) = nuclear receptor subfamily 5 group A member 1 (show NR5A1 Proteins); Me1 = malic enzyme 1; Mthfd2 (show MTHFD2 Proteins) = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
This study showed that (2)H-labeled tracers enable dissection of NADPH production routes across cell types and environmental conditions.
ME1 expression was found to be mutant-KRAS-associated in an NSCLC mouse model.
p53 (show TP53 Proteins) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 (show TCF4 Proteins) in human and mouse cells
cytosolic or mitochondrial isoforms of malic enzyme do not affect glucose-stimulated insulin (show INS Proteins) secretion from rodent islets
although ME1 overexpression augments anaplerosis and glucose stimulated insulin (show INS Proteins) secretion in INS-1 832/13 cells, it is not likely involved in methyl succinate and glucose stimulated insulin (show INS Proteins) secretion in pancreatic islets
This lack of consistency across families, combined with the fact that the ME1 mutation is synonymous and that the two DECR1 (show DECR1 Proteins) polymorphisms are conservative, suggests that the associations found are not causative.
Transcript level of the porcine ME1 gene is affected by SNP in its 3'UTR, which is also associated with subcutaneous fat thickness.
Malic enzyme 1 genotype is associated with backfat thickness and meat quality traits in pigs.
Six novel SNPs, five in ME1 and one in NR0B2 (show NR0B2 Proteins), were identified as candidates that have effects on meat and carcass quality traits.
ME1-Dra I genotypes had a significant effect on cooking loss.
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
Malic enzyme, cytoplasmic
, NADP-dependent malic enzyme
, malate dehydrogenase
, malic enzyme 1, soluble
, pyruvic-malic carboxylase
, malic enzyme, supernatant
, cytosolic malic enzyme 1
, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
, malate dehydrogenase decarboxylase (NADP+)
, malic enzyme 1, NADP(+)-dependent, cytoplasmic (cytosolic, soluble)
, malic enzyme 1, NADP(+)-dependent, cytosolic
, cytosolic malic enzyme 1-like
, NADP-dependent malic enzyme-like