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Hypomethylation of CpG sites within the MSX1 gene is associated with resistant high-grade serous ovarian cancer at presentation and identifies expression of MSX1 as conferring platinum drug sensitivity.
MSX1 homeobox protein accumulation is associated with the secretory phase in endometrium of fertile couples, and is widely disrupted in infertile patients. It is the first study to examine MSX1 protein localization in the human endometrium, and supported by genetic findings in mice, suggests that genes regulated by MSX1 are linked to the loss of epithelial cell polarity required for uterine receptivity during implantation
a strong correlation between observed phenotypes and the location in the MSX1 protein structure of the disease causing mutations (review)
this study shows that MSX1 is an important component of RLR (show DHX58 Proteins)-mediated signaling and reveal mechanisms on innate immune responses against RNA viruses
MSX1 and DCLK1 (show DCLK1 Proteins) might be used in colorectal cancer detection or as target of cancer therapies.
We found the c.*6C > T variation in the MSX1 gene. This variant in the 3' untranslated region is located 6 bp downstream of the stop codon (TAG) in exon 2. We revealed a statistically significant association between the MSX1 c.*6C > T variant and Nonsyndromic cleft lip/palate in Turkey ( p = 0.01).
The results of this study suggest an association between CL/P susceptibility and SNP1 (show SNRNP70 Proteins), located near the MSX1 gene, in the Mexican population.
Our study showed that TGFA (show TGFA Proteins)/TGFB3 (show TGFB3 Proteins)/MSX1 gene polymorphisms were associated with congenital NSHI. The distribution of genotype frequencies and allele frequencies of TGFA (show TGFA Proteins) rs3771494, TGFB3 (show TGFB3 Proteins) rs3917201 and rs2268626, and MSX1 rs3821949 and rs62636562 were significantly different between the case and the control groups
MSX1 was able to inhibit the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway, and that the ability to regulate the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway is critical for MSX1 to suppress glioblastoma cell migration and invasion.
mutations in MSX1 gene might play an important role in hypodontia cases involving pre-molars and is a risk factor for this ethnic population mainly of Arabs and is first report linking these mutations with tooth agenesis.
Msx1 may play a role in repressing gene expression in the fetal and postnatal periods.
Full digit tip was regenerated only in the MSX1/2 group and was related to boosted Bmp4, Fgf8, and K14 gene expression and to limb-patterning properties resulting from Msx1 and Msx2 overexpression.
endocytic adaptor protein Numb (show NUMB Proteins) regulates the balance between neural and non-neural fates in Msx1 progenitors.
these data reveal a novel mechanism that the Bmp4 (show BMP4 Proteins)-Msx1 pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt (show WNT2 Proteins) antagonists.
Msx1 and Msx2 are expressed both in Primordial germ cell precursors and in neighboring somatic cells. Msx1(-/-); Msx2(-/-) mutant embryos have defects in Primordial germ cell migration as well as a reduced number of Primordial germ cells.
Functional analysis of each TE revealed step-by-step retroposition/transposition and co-option together with acquisition of a binding site for Msx1 for its full enhancer function during mammalian evolution.
Data show that the spatiotemporal expression of claudin-1 (show CLDN1 Proteins) is dysregulated in homeobox (show PRRX1 Proteins) (Msx) genes Msx1d/d/Msx2d/d uteri.
MSX1 linked the arterial shear stimulus to arteriogenic remodeling by activating the endothelial but not medial layer to a proinflammatory state because EC but not smooth muscle cell
Msx1 and Msx2 are direct transcriptional targets of Lhx2 (show LHX2 Proteins).
Msx1 appears to act as a modeling factor for membranous bone.
analysis of a BMP signaling pathway that regulates the expression of the odontogenic gene Msx1 and determines the fate of dental mesenchyme during early tooth development
Suppression of MSX1 affects oocyte maturation, embryo cleavage rate, and expression of numerous genes suggesting important role for MSX1 in embryo development.
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia.
, homeobox protein Hox-7
, homeobox protein MSX-1
, msh homeo box 1
, msh homeobox 1-like protein
, msh homeobox homolog 1
, homeo box, msh-like 1
, homeobox, msh-like 1
, muscle-segment homeobox
, msh homeo box homolog 1
, Hbox 7
, homeobox protein GHOX-7