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Gemin8 is a novel integral component of the SMN (show STMN1 Proteins) complex
Gemin8 has an essential role in the proper structural organization of the SMN (show STMN1 Proteins) complex and the involvement of the heteromeric subunit containing Gemin6 (show GEMIN6 Proteins), Gemin7 (show GEMIN7 Proteins), Gemin8, and Unrip (show STRAP Proteins) in the recruitment of Sm proteins to the snRNP (show LSM2 Proteins) assembly pathway
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.
family with sequence similarity 51, member A1
, gem-associated protein 8