anti-Human HER2 antibody for Neutralization

Recommended HER2 Antibody (supplied by: Log in to see )

Antigen
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • MLN 19
  • NEU
  • NGL
  • TKR1
  • Erbb-2
  • Neu
  • c-erbB2
  • c-neu
  • mKIAA3023
  • wu:fv70f10
  • zgc:63601
  • erb2
  • erb-b2 receptor tyrosine kinase 2
  • ERBB2
  • Erbb2
  • erbb2
Reactivity
Human
1268
397
294
28
21
8
4
4
4
4
3
3
3
2
1
1
1
Host
Human
774
564
30
14
11
3
2
Clonality
Monoclonal
Conjugate
This HER2 antibody is un-conjugated
59
45
44
42
41
27
19
19
13
12
12
12
10
10
8
8
8
8
8
7
7
7
7
7
7
7
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
3
2
2
1
Application
ELISA, Neutralization (Neut)
646
464
410
383
333
201
198
103
102
101
80
47
24
21
18
10
6
4
3
3
2
2
1
1
1
1
1
1
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Catalog No. ABIN4964940
$ 310.00
Plus shipping costs $45.00

General

Antigen V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
Reactivity Human
(1268), (397), (294), (28), (21), (8), (4), (4), (4), (4), (3), (3), (3), (2), (1), (1), (1)
Host Human
(774), (564), (30), (14), (11), (3), (2)
Clonality
Monoclonal
Conjugate This HER2 antibody is un-conjugated
(59), (45), (44), (42), (41), (27), (19), (19), (13), (12), (12), (12), (10), (10), (8), (8), (8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (3), (2), (2), (1)
Application ELISA, Neutralization (Neut)
(646), (464), (410), (383), (333), (201), (198), (103), (102), (101), (80), (47), (24), (21), (18), (10), (6), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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Product Details anti-HER2 Antibody

Target Details HER2 Application Details Handling Images
Purpose Monoclonal human IgG1 antibody against human HER2
Purification Human IgG1 was expressed in a human cell line. IgG was purified from CHO cell culture supernatant by protein A chromatography.
Immunogen Recombinant human epidermal growth factor receptor 2 (HER2)
Isotype IgG1
Plasmids, Primers & others

Target Details HER2

Product Details anti-HER2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name HER2 (ERBB2 Antibody Abstract)
Background Trastuzumab is a recombinant humanized monoclonal immunoglobulin G1 kappa antibody that binds with high affinity and specificity to the extracellular domain of the HER2 receptor. A growth factor receptor gene, human epidermal growth factor receptor (HER2), is amplified in 25 to 30 % of breast cancers and in these cases the encoded protein is present in abnormally high levels in the malignant cells. Trastuzumab is used to treat adjuvant and metastatic breast cancer as well as metastatic gastric cancer.
Synonyms: Herceptin
Gene ID 2064
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development

Application Details

Product Details anti-HER2 Antibody Target Details HER2 Handling Images back to top
Application Notes Neutralization : 1-20 μg/mL
ELISA: 2 μg/mL
Restrictions For Research Use only

Handling

Product Details anti-HER2 Antibody Target Details HER2 Application Details Images back to top
Format Liquid
Concentration 2 mg/mL
Buffer 100 μg (2 mg/mL) of antibody in Phosphate buffered saline, pH 7.4.
Handling Advice The antibody solution should be gently mixed before use
Storage -20 °C
Expiry Date 12 months