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|Antigen||Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibodies|
|Conjugate||This IGF1R antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
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Product Details anti-IGF1R AntibodyTarget Details IGF1R Application Details Handling References for anti-IGF1R antibody (ABIN359877) Images
|Specificity||This antibody reacts to IGF1 Receptor (IGF1R).|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human IGF1R.|
Target Details IGF1RProduct Details anti-IGF1R Antibody Application Details Handling References for anti-IGF1R antibody (ABIN359877) Images back to top
|Alternative Name||CD221 / IGF1R (IGF1R Antibody Abstract)|
|Background||The IGF1R receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.Synonyms: IGF-I receptor, IGF1 Receptor, Insulin-like growth factor 1 receptor|
|Gene ID||3480, 9606|
|Pathways||RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy|
Application DetailsProduct Details anti-IGF1R Antibody Target Details IGF1R Handling References for anti-IGF1R antibody (ABIN359877) Images back to top
ELISA: 1/1,000. Western Blot: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IGF1R Antibody Target Details IGF1R Application Details References for anti-IGF1R antibody (ABIN359877) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-IGF1R antibody (ABIN359877)Product Details anti-IGF1R Antibody Target Details IGF1R Application Details Handling Images back to top
Song, Barnes, Zhang, Bao, Kumar, Santen: "The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 7, pp. 2076-81, 2004
Staes, Demol, Van Damme, Martens, Vandekerckhove, Gevaert: "Global differential non-gel proteomics by quantitative and stable labeling of tryptic peptides with oxygen-18." in: Journal of proteome research, Vol. 3, Issue 4, pp. 786-91, 2004
Lu, Zi, Zhao, Pollak: "Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells." in: Biochemical and biophysical research communications, Vol. 313, Issue 3, pp. 709-15, 2003
Hakam, Fang, Karl, Coppola: "Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma." in: Digestive diseases and sciences, Vol. 48, Issue 10, pp. 1972-8, 2003
Li, Higashi, Itabe, Song, Du, Delafontaine: "Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the phosphatidylinositol 3 kinase/Akt signaling pathway." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 23, Issue 12, pp. 2178-84, 2003
ImagesProduct Details anti-IGF1R Antibody Target Details IGF1R Application Details Handling References for anti-IGF1R antibody (ABIN359877) back to top