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Findings reveal an intimate reciprocal relationship between ErbB4 (show ERBB4 Proteins) and GluN2b (show GRIN2B Proteins) NMDA receptors via NRG2/ErbB4 (show ERBB4 Proteins) signaling.
The distinct temporal, regional, and subcellular expression of NRG-2 in the developing brain suggests its unique and nonredundant role in neural function.
in vivo NRG-2 activity differs substantially from that of NRG-1 (show NRG1 Proteins), and it is not essential for normal development
identify NRG2 as a factor capable of promoting subventricular zone proliferation, leading to the formation of new neurons in vivo
reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress.
Nrg-2-induced Acetylcholine Receptor (show CHRNA1 Proteins) transcription requires an N-box motif and is regulated by alternative splicing.
Linkage interval for GLC1M (show EFNA5 Proteins) was refined to a smaller region. The NRG2 gene was excluded as the causative gene for juvenile-onset primary open angle glaucoma.
Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 (show ERBB4 Proteins) coupling to IL3 (show IL-3 Proteins) independence.
NRG2 was positive in almost all breast cancers studied. High expression is related to the biological aggressiveness of breast cancer.
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described.
, pro-neuregulin-2, membrane-bound isoform
, divergent of neuregulin-1
, neural- and thymus-derived activator for ErbB kinases
, NTAK alpha1