|Antigen||Neuregulin 3 (NRG3) Antibodies|
|Conjugate||This Neuregulin 3 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Product Details anti-Neuregulin 3 AntibodyTarget Details Neuregulin 3 Application Details Handling Images
|Specificity||This antibody detects Neuregulin-3 (NRG-3/NRG3).|
|Immunogen||Synthetic peptide of Neuregulin-3 (NRG-3/NRG3) - KLH conjugated|
Target Details Neuregulin 3Product Details anti-Neuregulin 3 Antibody Application Details Handling Images back to top
|Alternative Name||Neuregulin 3 (NRG3 Antibody Abstract)|
|Background||NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization. There are 4 different isoforms.Synonyms: NRG3, Pro-NRG3, Pro-neuregulin-3, membrane-bound isoform|
Application DetailsProduct Details anti-Neuregulin 3 Antibody Target Details Neuregulin 3 Handling Images back to top
Immunohistochemistry on paraffin sections (20 μg/mL). ELISA (1: 0 - 1: 1000). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
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|Buffer||Phosphate buffered saline containing 0.09 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||DO NOT FREEZE!!|
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